FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2773350863> ?p ?o ?g. }

• W2773350863 endingPage "169" @default.
• W2773350863 startingPage "155" @default.
• W2773350863 abstract "The number of targeted therapies utilized in precision medicine are rapidly increasing. Neuro-oncology offers a unique challenge due to the varying blood brain barrier (BBB) penetration of each agent. Neuro-oncologists face a difficult task weighing the growing number of potential targeted therapies and their likelihood of BBB penetration. We developed the CNS TAP Working Group and performed an extensive literature review for the evidence-based creation of the CNS TAP tool, which was retrospectively validated by analyzing brain tumor patients who underwent therapy targeted based on genomic results from an academic sequencing study (MiOncoseq, n = 17) or private molecular profiling (Foundation One, n = 7). The CNS TAP tool scores relevant targeted agents by applying multiple variables (i.e., pre-clinical data, clinical data, BBB permeability) to patient specific genomic information and clinical trial availability. In the Michigan cohort, the CNS TAP tool predicted the selected agent 85.7% of the time. The CNS TAP tool predicted the agent independently selected by pediatric neuro-oncologists in the Colorado cohort 50% of the time. Patients with recurrent brain tumors treated with agents predicted by the CNS TAP tool demonstrated a median progression-free survival of 4 months and four patients with recurrent high-grade glioma maintained ongoing partial responses of at least 6 months. The CNS TAP tool is a formalized algorithm to assist clinicians select the optimal targeted therapy for neuro-oncology patients. The CNS TAP tool has relatively high concordance with selected therapies and clinical outcomes in patients receiving targeted therapy in this heterogeneous retrospective cohort were promising." @default.
• W2773350863 created "2017-12-22" @default.
• W2773350863 creator A5001293585 @default.
• W2773350863 creator A5003311852 @default.
• W2773350863 creator A5006569511 @default.
• W2773350863 creator A5014330639 @default.
• W2773350863 creator A5034593133 @default.
• W2773350863 creator A5038541985 @default.
• W2773350863 creator A5039164204 @default.
• W2773350863 creator A5044840812 @default.
• W2773350863 creator A5050494156 @default.
• W2773350863 creator A5063344282 @default.
• W2773350863 creator A5073294664 @default.
• W2773350863 creator A5078830268 @default.
• W2773350863 creator A5084587717 @default.
• W2773350863 creator A5086113297 @default.
• W2773350863 date "2017-12-12" @default.
• W2773350863 modified "2023-10-15" @default.
• W2773350863 title "Development of the CNS TAP tool for the selection of precision medicine therapies in neuro-oncology" @default.
• W2773350863 cites W1911918948 @default.
• W2773350863 cites W1991803873 @default.
• W2773350863 cites W2011097571 @default.
• W2773350863 cites W2017423154 @default.
• W2773350863 cites W2049055032 @default.
• W2773350863 cites W2058743530 @default.
• W2773350863 cites W2064808628 @default.
• W2773350863 cites W2073367400 @default.
• W2773350863 cites W2107977954 @default.
• W2773350863 cites W2112754885 @default.
• W2773350863 cites W2116631246 @default.
• W2773350863 cites W2133198620 @default.
• W2773350863 cites W2140293712 @default.
• W2773350863 cites W2143618395 @default.
• W2773350863 cites W2150442140 @default.
• W2773350863 cites W2208625206 @default.
• W2773350863 cites W2272820807 @default.
• W2773350863 cites W2303158491 @default.
• W2773350863 cites W2320523858 @default.
• W2773350863 cites W2342679175 @default.
• W2773350863 cites W2423489009 @default.
• W2773350863 cites W2528841444 @default.
• W2773350863 cites W2554921042 @default.
• W2773350863 cites W2566723262 @default.
• W2773350863 cites W2614672103 @default.
• W2773350863 cites W2617990204 @default.
• W2773350863 cites W2741363425 @default.
• W2773350863 cites W2742528520 @default.
• W2773350863 cites W817872913 @default.
• W2773350863 doi "https://doi.org/10.1007/s11060-017-2708-1" @default.
• W2773350863 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5823756" @default.
• W2773350863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29235051" @default.
• W2773350863 hasPublicationYear "2017" @default.
• W2773350863 type Work @default.
• W2773350863 sameAs 2773350863 @default.
• W2773350863 citedByCount "11" @default.
• W2773350863 countsByYear W27733508632018 @default.
• W2773350863 countsByYear W27733508632019 @default.
• W2773350863 countsByYear W27733508632020 @default.
• W2773350863 countsByYear W27733508632021 @default.
• W2773350863 countsByYear W27733508632022 @default.
• W2773350863 countsByYear W27733508632023 @default.
• W2773350863 crossrefType "journal-article" @default.
• W2773350863 hasAuthorship W2773350863A5001293585 @default.
• W2773350863 hasAuthorship W2773350863A5003311852 @default.
• W2773350863 hasAuthorship W2773350863A5006569511 @default.
• W2773350863 hasAuthorship W2773350863A5014330639 @default.
• W2773350863 hasAuthorship W2773350863A5034593133 @default.
• W2773350863 hasAuthorship W2773350863A5038541985 @default.
• W2773350863 hasAuthorship W2773350863A5039164204 @default.
• W2773350863 hasAuthorship W2773350863A5044840812 @default.
• W2773350863 hasAuthorship W2773350863A5050494156 @default.
• W2773350863 hasAuthorship W2773350863A5063344282 @default.
• W2773350863 hasAuthorship W2773350863A5073294664 @default.
• W2773350863 hasAuthorship W2773350863A5078830268 @default.
• W2773350863 hasAuthorship W2773350863A5084587717 @default.
• W2773350863 hasAuthorship W2773350863A5086113297 @default.
• W2773350863 hasBestOaLocation W27733508632 @default.
• W2773350863 hasConcept C121608353 @default.
• W2773350863 hasConcept C126322002 @default.
• W2773350863 hasConcept C143998085 @default.
• W2773350863 hasConcept C160798450 @default.
• W2773350863 hasConcept C2778227246 @default.
• W2773350863 hasConcept C2781230642 @default.
• W2773350863 hasConcept C502942594 @default.
• W2773350863 hasConcept C535046627 @default.
• W2773350863 hasConcept C71924100 @default.
• W2773350863 hasConcept C72563966 @default.
• W2773350863 hasConceptScore W2773350863C121608353 @default.
• W2773350863 hasConceptScore W2773350863C126322002 @default.
• W2773350863 hasConceptScore W2773350863C143998085 @default.
• W2773350863 hasConceptScore W2773350863C160798450 @default.
• W2773350863 hasConceptScore W2773350863C2778227246 @default.
• W2773350863 hasConceptScore W2773350863C2781230642 @default.
• W2773350863 hasConceptScore W2773350863C502942594 @default.
• W2773350863 hasConceptScore W2773350863C535046627 @default.
• W2773350863 hasConceptScore W2773350863C71924100 @default.
• W2773350863 hasConceptScore W2773350863C72563966 @default.
• W2773350863 hasFunder F4320332161 @default.

• next