FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2773379551> ?p ?o ?g. }

• W2773379551 abstract "Adipose-derived stromal cells (ASCs) have gained great attention in regenerative medicine. Progress in our understanding of adult neovascularization further suggests the potential of ASCs in promoting vascular regeneration, although the specific cues that stimulate their angiogenic behavior remain controversial. In this study, we established a three-dimensional (3D) angiogenesis model by co-culturing ASCs and endothelial cells (ECs) in collagen gel and found that ASC-EC-instructed angiogenesis was regulated by the canonical Wnt pathway. Furthermore, the angiogenesis that occurred in implants collected after injections of our collagen gel-based 3D angiogenesis model into nude mice was confirmed to be functional and also regulated by the canonical Wnt pathway. Wnt regulation of angiogenesis involving changes in vessel length, vessel density, vessel sprout, and connection numbers occurred in our system. Wnt signaling was then shown to regulate ASC-mediated paracrine signaling during angiogenesis through the nuclear translocation of β-catenin after its cytoplasmic accumulation in both ASCs and ECs. This translocation enhanced the expression of nuclear co-factor Lef-1 and cyclin D1 and activated the angiogenic transcription of vascular endothelial growth factor A (VEGFA), basic fibroblast growth factor (bFGF), and insulin-like growth factor 1 (IGF-1). The angiogenesis process in the 3D collagen model appeared to follow canonical Wnt signaling, and this model can help us understand the importance of the canonical Wnt pathway in the use of ASCs in vascular regeneration." @default.
• W2773379551 created "2017-12-22" @default.
• W2773379551 creator A5004500338 @default.
• W2773379551 creator A5006850260 @default.
• W2773379551 creator A5016021980 @default.
• W2773379551 creator A5019836221 @default.
• W2773379551 creator A5032209214 @default.
• W2773379551 creator A5038223127 @default.
• W2773379551 creator A5057922659 @default.
• W2773379551 creator A5063022734 @default.
• W2773379551 date "2017-12-13" @default.
• W2773379551 modified "2023-10-17" @default.
• W2773379551 title "Angiogenesis in a 3D model containing adipose tissue stem cells and endothelial cells is mediated by canonical Wnt signaling" @default.
• W2773379551 cites W1532597512 @default.
• W2773379551 cites W1589352523 @default.
• W2773379551 cites W1794475703 @default.
• W2773379551 cites W1875912426 @default.
• W2773379551 cites W1929831514 @default.
• W2773379551 cites W1941535010 @default.
• W2773379551 cites W1968129433 @default.
• W2773379551 cites W1971481846 @default.
• W2773379551 cites W1977508482 @default.
• W2773379551 cites W1979024702 @default.
• W2773379551 cites W2016305198 @default.
• W2773379551 cites W2016701686 @default.
• W2773379551 cites W2025406984 @default.
• W2773379551 cites W2028205170 @default.
• W2773379551 cites W2035809306 @default.
• W2773379551 cites W2039092880 @default.
• W2773379551 cites W2040089666 @default.
• W2773379551 cites W2049487321 @default.
• W2773379551 cites W2057759091 @default.
• W2773379551 cites W2068118782 @default.
• W2773379551 cites W2088049803 @default.
• W2773379551 cites W2089449028 @default.
• W2773379551 cites W2096599017 @default.
• W2773379551 cites W2106343755 @default.
• W2773379551 cites W2113185920 @default.
• W2773379551 cites W2117156715 @default.
• W2773379551 cites W2121370170 @default.
• W2773379551 cites W2124857894 @default.
• W2773379551 cites W2125266532 @default.
• W2773379551 cites W2143758659 @default.
• W2773379551 cites W2146590089 @default.
• W2773379551 cites W2147553923 @default.
• W2773379551 cites W2152442991 @default.
• W2773379551 cites W2210646961 @default.
• W2773379551 cites W2279292071 @default.
• W2773379551 cites W2329463314 @default.
• W2773379551 cites W2340426232 @default.
• W2773379551 cites W2347106608 @default.
• W2773379551 cites W2499822005 @default.
• W2773379551 cites W2513356113 @default.
• W2773379551 cites W2523016801 @default.
• W2773379551 doi "https://doi.org/10.1038/boneres.2017.48" @default.
• W2773379551 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5727463" @default.
• W2773379551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29263938" @default.
• W2773379551 hasPublicationYear "2017" @default.
• W2773379551 type Work @default.
• W2773379551 sameAs 2773379551 @default.
• W2773379551 citedByCount "49" @default.
• W2773379551 countsByYear W27733795512017 @default.
• W2773379551 countsByYear W27733795512018 @default.
• W2773379551 countsByYear W27733795512019 @default.
• W2773379551 countsByYear W27733795512020 @default.
• W2773379551 countsByYear W27733795512021 @default.
• W2773379551 countsByYear W27733795512022 @default.
• W2773379551 countsByYear W27733795512023 @default.
• W2773379551 crossrefType "journal-article" @default.
• W2773379551 hasAuthorship W2773379551A5004500338 @default.
• W2773379551 hasAuthorship W2773379551A5006850260 @default.
• W2773379551 hasAuthorship W2773379551A5016021980 @default.
• W2773379551 hasAuthorship W2773379551A5019836221 @default.
• W2773379551 hasAuthorship W2773379551A5032209214 @default.
• W2773379551 hasAuthorship W2773379551A5038223127 @default.
• W2773379551 hasAuthorship W2773379551A5057922659 @default.
• W2773379551 hasAuthorship W2773379551A5063022734 @default.
• W2773379551 hasBestOaLocation W27733795511 @default.
• W2773379551 hasConcept C134018914 @default.
• W2773379551 hasConcept C137620995 @default.
• W2773379551 hasConcept C146285616 @default.
• W2773379551 hasConcept C167734588 @default.
• W2773379551 hasConcept C170493617 @default.
• W2773379551 hasConcept C171089720 @default.
• W2773379551 hasConcept C185592680 @default.
• W2773379551 hasConcept C2777025900 @default.
• W2773379551 hasConcept C2778271429 @default.
• W2773379551 hasConcept C2780394083 @default.
• W2773379551 hasConcept C502942594 @default.
• W2773379551 hasConcept C54355233 @default.
• W2773379551 hasConcept C62478195 @default.
• W2773379551 hasConcept C74373430 @default.
• W2773379551 hasConcept C7876069 @default.
• W2773379551 hasConcept C86803240 @default.
• W2773379551 hasConcept C95444343 @default.
• W2773379551 hasConceptScore W2773379551C134018914 @default.
• W2773379551 hasConceptScore W2773379551C137620995 @default.
• W2773379551 hasConceptScore W2773379551C146285616 @default.
• W2773379551 hasConceptScore W2773379551C167734588 @default.
• W2773379551 hasConceptScore W2773379551C170493617 @default.

• next