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• W2773380467 startingPage "1303" @default.
• W2773380467 abstract "NMDA receptors (NMDARs) are a subtype of postsynaptic ionotropic glutamate receptors that function as molecular coincidence detectors, have critical roles in models of learning, and are associated with a variety of neurological and psychiatric disorders. To date, no auxiliary proteins that modify NMDARs have been identified. Here, we report the identification of NRAP-1, an auxiliary protein in C. elegans that modulates NMDAR function. NMDAR-mediated currents were eliminated in nrap-1 mutants, as was NMDA-dependent behavior. We show that reconstitution of NMDA-gated current in Xenopus oocytes, or C. elegans muscle cells, depends on NRAP-1 and that recombinant NRAP-1 can convert silent NMDARs to functional channels. Our data indicate that NRAP-1, secreted from presynaptic neurons, localizes to glutamatergic synapses, where it associates with postsynaptic NMDARs to modify receptor gating. Thus, our studies reveal a novel mechanism for synaptic regulation via pre-synaptic control of NMDAR-mediated synaptic transmission." @default.
• W2773380467 created "2017-12-22" @default.
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• W2773380467 date "2017-12-01" @default.
• W2773380467 modified "2023-10-05" @default.
• W2773380467 title "NRAP-1 Is a Presynaptically Released NMDA Receptor Auxiliary Protein that Modifies Synaptic Strength" @default.
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• W2773380467 doi "https://doi.org/10.1016/j.neuron.2017.11.019" @default.
• W2773380467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29224722" @default.
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