Matches in SemOpenAlex for { <https://semopenalex.org/work/W2773483244> ?p ?o ?g. }
- W2773483244 endingPage "487" @default.
- W2773483244 startingPage "482" @default.
- W2773483244 abstract "A series of 5-substitutedbenzylideneamino-2-butylbenzofuran-3-yl-4-methoxyphenyl methanones is synthesized and evaluated for antileishmanial and antioxidant activities. Compounds 4f (IC50 = 52.0 ± 0.09 µg/ml), 4h (IC50 = 56.0 ± 0.71 µg/ml) and 4l (IC50 = 59.3 ± 0.55 µg/ml) were shown significant antileishmanial when compared with standard sodium stibogluconate (IC50 = 490.0 ± 1.5 µg/ml). Antioxidant study revealed that compounds 4i (IC50 = 2.44 ± 0.47 µg/ml) and 4l (IC50 = 3.69 ± 0.44 µg/ml) have shown potent comparable activity when compared with standard ascorbic acid (IC50 = 3.31 ± 0.34 µg/ml). Molecular docking study was carried out which replicating results of biological activity in case of initial hits 4f and 4h suggesting that these compounds have a potential to become lead molecules in drug discovery process. In silico ADME study was performed for predicting pharmacokinetic profile of the synthesised antileishmanial agents and expressed good oral drug like behaviour." @default.
- W2773483244 created "2017-12-22" @default.
- W2773483244 creator A5001161450 @default.
- W2773483244 creator A5002485284 @default.
- W2773483244 creator A5029254677 @default.
- W2773483244 creator A5046425895 @default.
- W2773483244 creator A5049726655 @default.
- W2773483244 creator A5056484690 @default.
- W2773483244 creator A5064937130 @default.
- W2773483244 creator A5086267780 @default.
- W2773483244 date "2018-02-01" @default.
- W2773483244 modified "2023-10-16" @default.
- W2773483244 title "Microwave-assisted synthesis of novel 5-substituted benzylidene amino-2-butyl benzofuran-3-yl-4-methoxyphenyl methanones as antileishmanial and antioxidant agents" @default.
- W2773483244 cites W191227402 @default.
- W2773483244 cites W1985062061 @default.
- W2773483244 cites W1995789505 @default.
- W2773483244 cites W1997213089 @default.
- W2773483244 cites W1999809189 @default.
- W2773483244 cites W2002769318 @default.
- W2773483244 cites W2029305163 @default.
- W2773483244 cites W2032920841 @default.
- W2773483244 cites W2033495141 @default.
- W2773483244 cites W2048740663 @default.
- W2773483244 cites W2058897578 @default.
- W2773483244 cites W2066454516 @default.
- W2773483244 cites W2068138365 @default.
- W2773483244 cites W2074285227 @default.
- W2773483244 cites W2074485146 @default.
- W2773483244 cites W2083678132 @default.
- W2773483244 cites W2084500214 @default.
- W2773483244 cites W2084929244 @default.
- W2773483244 cites W2106784812 @default.
- W2773483244 cites W2120349335 @default.
- W2773483244 cites W2135732933 @default.
- W2773483244 cites W2313388645 @default.
- W2773483244 cites W2332716720 @default.
- W2773483244 cites W2462729766 @default.
- W2773483244 cites W2951440100 @default.
- W2773483244 cites W759197525 @default.
- W2773483244 doi "https://doi.org/10.1016/j.bmcl.2017.12.013" @default.
- W2773483244 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29258770" @default.
- W2773483244 hasPublicationYear "2018" @default.
- W2773483244 type Work @default.
- W2773483244 sameAs 2773483244 @default.
- W2773483244 citedByCount "8" @default.
- W2773483244 countsByYear W27734832442018 @default.
- W2773483244 countsByYear W27734832442019 @default.
- W2773483244 countsByYear W27734832442020 @default.
- W2773483244 countsByYear W27734832442021 @default.
- W2773483244 countsByYear W27734832442022 @default.
- W2773483244 countsByYear W27734832442023 @default.
- W2773483244 crossrefType "journal-article" @default.
- W2773483244 hasAuthorship W2773483244A5001161450 @default.
- W2773483244 hasAuthorship W2773483244A5002485284 @default.
- W2773483244 hasAuthorship W2773483244A5029254677 @default.
- W2773483244 hasAuthorship W2773483244A5046425895 @default.
- W2773483244 hasAuthorship W2773483244A5049726655 @default.
- W2773483244 hasAuthorship W2773483244A5056484690 @default.
- W2773483244 hasAuthorship W2773483244A5064937130 @default.
- W2773483244 hasAuthorship W2773483244A5086267780 @default.
- W2773483244 hasConcept C104317684 @default.
- W2773483244 hasConcept C185592680 @default.
- W2773483244 hasConcept C202751555 @default.
- W2773483244 hasConcept C2775905019 @default.
- W2773483244 hasConcept C2776589655 @default.
- W2773483244 hasConcept C2777752497 @default.
- W2773483244 hasConcept C2778004101 @default.
- W2773483244 hasConcept C2986274086 @default.
- W2773483244 hasConcept C31903555 @default.
- W2773483244 hasConcept C41847442 @default.
- W2773483244 hasConcept C55493867 @default.
- W2773483244 hasConcept C69366308 @default.
- W2773483244 hasConcept C71240020 @default.
- W2773483244 hasConcept C71924100 @default.
- W2773483244 hasConcept C98274493 @default.
- W2773483244 hasConceptScore W2773483244C104317684 @default.
- W2773483244 hasConceptScore W2773483244C185592680 @default.
- W2773483244 hasConceptScore W2773483244C202751555 @default.
- W2773483244 hasConceptScore W2773483244C2775905019 @default.
- W2773483244 hasConceptScore W2773483244C2776589655 @default.
- W2773483244 hasConceptScore W2773483244C2777752497 @default.
- W2773483244 hasConceptScore W2773483244C2778004101 @default.
- W2773483244 hasConceptScore W2773483244C2986274086 @default.
- W2773483244 hasConceptScore W2773483244C31903555 @default.
- W2773483244 hasConceptScore W2773483244C41847442 @default.
- W2773483244 hasConceptScore W2773483244C55493867 @default.
- W2773483244 hasConceptScore W2773483244C69366308 @default.
- W2773483244 hasConceptScore W2773483244C71240020 @default.
- W2773483244 hasConceptScore W2773483244C71924100 @default.
- W2773483244 hasConceptScore W2773483244C98274493 @default.
- W2773483244 hasIssue "3" @default.
- W2773483244 hasLocation W27734832441 @default.
- W2773483244 hasLocation W27734832442 @default.
- W2773483244 hasOpenAccess W2773483244 @default.
- W2773483244 hasPrimaryLocation W27734832441 @default.
- W2773483244 hasRelatedWork W1229371060 @default.
- W2773483244 hasRelatedWork W2127910710 @default.
- W2773483244 hasRelatedWork W2356609951 @default.