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• W2773697958 endingPage "e0187191" @default.
• W2773697958 startingPage "e0187191" @default.
• W2773697958 abstract "Multiple drug resistant (MDR) malignancy remains a predictable and often terminal event in cancer therapy, and affects individuals with many cancer types, regardless of the stage at which they were originally diagnosed or the interval from last treatment. Protein biomarkers of MDR are not globally used for clinical decision-making, but include the overexpression of drug-efflux pumps (ABC transporter family) such as MDR-1 and BCRP, as well as HIF1α, a stress responsive transcription factor found elevated within many MDR tumors. Here, we present the important in vitro discovery that the development of MDR (in breast cancer cells) can be prevented, and that established MDR could be resensitized to therapy, by adjunct treatment with metformin. Metformin is prescribed globally to improve insulin sensitivity, including in those individuals with Type 2 Diabetes Mellitus (DM2). We demonstrate the effectiveness of metformin in resensitizing MDR breast cancer cell lines to their original treatment, and provide evidence that metformin may function through a mechanism involving post-translational histone modifications via an indirect histone deacetylase inhibitor (HDACi) activity. We find that metformin, at low physiological concentrations, reduces the expression of multiple classic protein markers of MDR in vitro and in preliminary in vivo models. Our demonstration that metformin can prevent MDR development and resensitize MDR cells to chemotherapy in vitro, provides important medical relevance towards metformin’s potential clinical use against MDR cancers." @default.
• W2773697958 created "2017-12-22" @default.
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• W2773697958 date "2017-12-06" @default.
• W2773697958 modified "2023-10-16" @default.
• W2773697958 title "Metformin inhibits the development, and promotes the resensitization, of treatment-resistant breast cancer" @default.
• W2773697958 cites W1502235325 @default.
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• W2773697958 cites W1860513253 @default.
• W2773697958 cites W1964423199 @default.
• W2773697958 cites W1967231442 @default.
• W2773697958 cites W1972115097 @default.
• W2773697958 cites W1974308863 @default.
• W2773697958 cites W1974825648 @default.
• W2773697958 cites W1975425183 @default.
• W2773697958 cites W1976655891 @default.
• W2773697958 cites W1977760098 @default.
• W2773697958 cites W1983690350 @default.
• W2773697958 cites W1994792821 @default.
• W2773697958 cites W1999251458 @default.
• W2773697958 cites W2004459316 @default.
• W2773697958 cites W2005832736 @default.
• W2773697958 cites W2006851815 @default.
• W2773697958 cites W2009900582 @default.
• W2773697958 cites W2009984834 @default.
• W2773697958 cites W2014885180 @default.
• W2773697958 cites W2020239218 @default.
• W2773697958 cites W2028598028 @default.
• W2773697958 cites W2029376990 @default.
• W2773697958 cites W2032167680 @default.
• W2773697958 cites W2040031153 @default.
• W2773697958 cites W2046581895 @default.
• W2773697958 cites W2050522518 @default.
• W2773697958 cites W2063342829 @default.
• W2773697958 cites W2077311759 @default.
• W2773697958 cites W2077505355 @default.
• W2773697958 cites W2081833877 @default.
• W2773697958 cites W2085609942 @default.
• W2773697958 cites W2085950913 @default.
• W2773697958 cites W2091719230 @default.
• W2773697958 cites W2092476693 @default.
• W2773697958 cites W2099472440 @default.
• W2773697958 cites W2100511132 @default.
• W2773697958 cites W2100544199 @default.
• W2773697958 cites W2104216849 @default.
• W2773697958 cites W2110361622 @default.
• W2773697958 cites W2110378444 @default.
• W2773697958 cites W2116531861 @default.
• W2773697958 cites W2121519011 @default.
• W2773697958 cites W2130429000 @default.
• W2773697958 cites W2134907909 @default.
• W2773697958 cites W2138648988 @default.
• W2773697958 cites W2148755064 @default.
• W2773697958 cites W2158731007 @default.
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• W2773697958 cites W2164620725 @default.
• W2773697958 cites W2169666080 @default.
• W2773697958 cites W2187095718 @default.
• W2773697958 cites W2204526245 @default.
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• W2773697958 cites W2271195953 @default.
• W2773697958 cites W2295697823 @default.
• W2773697958 cites W2339623449 @default.
• W2773697958 cites W2398760267 @default.
• W2773697958 cites W2417470860 @default.
• W2773697958 cites W2418622096 @default.
• W2773697958 cites W2479507898 @default.
• W2773697958 cites W2493221114 @default.
• W2773697958 cites W2524637936 @default.
• W2773697958 cites W2572535868 @default.
• W2773697958 cites W2577527422 @default.
• W2773697958 cites W2579248938 @default.
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• W2773697958 doi "https://doi.org/10.1371/journal.pone.0187191" @default.
• W2773697958 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5718420" @default.
• W2773697958 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29211738" @default.
• W2773697958 hasPublicationYear "2017" @default.
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