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• W2773719983 abstract "The insertion/deletion polymorphism in the gene for the regulator of vascular tone, angiotensin-converting enzyme (ACE), is the prototype of a genetic influence on physical fitness and this involves an influence on capillary supply lines and dependent aerobic metabolism in skeletal muscle. The respective interaction of ACE-I/D genotype and training status on local metabolic and angiogenic reactions in exercised muscle is not known. Towards this end we characterized the metabolomic and angiogenic response in knee extensor muscle, m. vastus lateralis, in 18 untrained and 34 endurance-trained (physically active, VO2max>50 mL min-1 kg-1) white British men to an exhaustive bout of one-legged cycling exercise. We hypothesized that training status and ACE-I/D genotype affect supply-related muscle characteristics of exercise performance in correspondence to ACE expression and angiotensin 2 levels. ACE-I/D genotype and training status developed an interaction effect on the cross-sectional area (CSA) of m. vastus lateralis and mean CSA of slow type fibers, which correlated with peak power output (r≥0.44). Genotype x training interactions in muscle also resolved for exercise-induced alterations of 22 metabolites, 8 lipids, glycogen concentration (p=0.016), ACE transcript levels (p=0.037), and by trend for the pro-angiogenic factor tenascin-C post exercise (p=0.064). Capillary density (p=0.001), capillary-to-fiber ratio (p=0.010), systolic blood pressure (p=0.014), and exercise-induced alterations in the pro-angiogenic protein VEGF (p=0.043) depended on the ACE-I/D genotype alone. Our observations indicate that variability in aerobic performance in the studied subjects was in part reflected by an ACE-I/D-genotype-modulated metabolic phenotype of a major locomotor muscle. Repeated endurance exercise appeared to override this genetic influence in skeletal muscle by altering the ACE-related metabolic response and molecular aspects of the angiogenic response to endurance exercise." @default.
• W2773719983 created "2017-12-22" @default.
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• W2773719983 date "2017-12-14" @default.
• W2773719983 modified "2023-10-14" @default.
• W2773719983 title "The Metabolic Response of Skeletal Muscle to Endurance Exercise Is Modified by the ACE-I/D Gene Polymorphism and Training State" @default.
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• W2773719983 cites W1582334575 @default.
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• W2773719983 cites W1990589505 @default.
• W2773719983 cites W1994038070 @default.
• W2773719983 cites W1995381409 @default.
• W2773719983 cites W1996291620 @default.
• W2773719983 cites W2003256234 @default.
• W2773719983 cites W2004886666 @default.
• W2773719983 cites W2016952042 @default.
• W2773719983 cites W2019958686 @default.
• W2773719983 cites W2021823221 @default.
• W2773719983 cites W2025901279 @default.
• W2773719983 cites W2034151194 @default.
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• W2773719983 cites W2048667592 @default.
• W2773719983 cites W2051132285 @default.
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• W2773719983 cites W2066782344 @default.
• W2773719983 cites W2069169216 @default.
• W2773719983 cites W2070048536 @default.
• W2773719983 cites W2082556380 @default.
• W2773719983 cites W2087309105 @default.
• W2773719983 cites W2087325217 @default.
• W2773719983 cites W2097532633 @default.
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• W2773719983 cites W2167107375 @default.
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• W2773719983 cites W2230229343 @default.
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• W2773719983 doi "https://doi.org/10.3389/fphys.2017.00993" @default.
• W2773719983 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5735290" @default.
• W2773719983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29311951" @default.
• W2773719983 hasPublicationYear "2017" @default.
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