FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2773856285> ?p ?o ?g. }

• W2773856285 endingPage "1644" @default.
• W2773856285 startingPage "1639" @default.
• W2773856285 abstract "The beneficial effects of red wine against cardiovascular disease are associated with the abundant antioxidant polyphenols such as procyanidins. Recently, procyanidins extracted from the litchi pericarp (LPPC), a new source of procyanidins showed strong antioxidant activities in vitro, have been isolated and identified in our laboratory. The aim of present study was to investigate the anti-atherosclerotic effects of LPPC on atherosclerosis and hyperlipidemia in apolipoprotein E knockout (ApoE KO) mice fed a high fat diet (HFD, 21% fat, 0.15% cholesterol) for 24 weeks. The results showed that LPPC intervention alleviated atherosclerosis, fat accumulation and hyperlipidemia in ApoE KO mice. Furthermore, real-time RT-PCR results showed that LPPC can regulate several key genes involved in hepatic lipid homeostasis, such as increasing mRNA levels of farnesoid X receptor (FXR) and small heterodimer partner (SHP) which emerge as key regulators of lipid homeostasis at the transcriptional level, decreasing mRNA levels of 3-hydroxy-3-Methylglutaryl (HMG)-CoA reductase which mediates cholestrol biosynthesis, and up-regulating the mRNA expressions of ATP-binding cassette transporter-1 (ABCA1) which modulates cholesterol efflux. Thus, these results elucidated that LPPC could alleviate the lipid disorder especially hypercholesteromia and ameliorate atherosclerosis in ApoE-KO mice fed a WTD via regulating gene expression involved in hepatic lipid homeostasis effectively." @default.
• W2773856285 created "2017-12-22" @default.
• W2773856285 creator A5003355798 @default.
• W2773856285 creator A5007067761 @default.
• W2773856285 creator A5028912813 @default.
• W2773856285 creator A5034306021 @default.
• W2773856285 creator A5047388991 @default.
• W2773856285 creator A5058306320 @default.
• W2773856285 creator A5066716873 @default.
• W2773856285 creator A5083896582 @default.
• W2773856285 date "2018-01-01" @default.
• W2773856285 modified "2023-10-10" @default.
• W2773856285 title "Procyanidins extracted from the litchi pericarp attenuate atherosclerosis and hyperlipidemia associated with consumption of a high fat diet in apolipoprotein-E knockout mice" @default.
• W2773856285 cites W1966229285 @default.
• W2773856285 cites W1984416719 @default.
• W2773856285 cites W1992553704 @default.
• W2773856285 cites W2000061441 @default.
• W2773856285 cites W2000878794 @default.
• W2773856285 cites W2001058921 @default.
• W2773856285 cites W2007876572 @default.
• W2773856285 cites W2029080783 @default.
• W2773856285 cites W2038654926 @default.
• W2773856285 cites W2041232193 @default.
• W2773856285 cites W2049655058 @default.
• W2773856285 cites W2058273503 @default.
• W2773856285 cites W2072278477 @default.
• W2773856285 cites W2076524169 @default.
• W2773856285 cites W2093128178 @default.
• W2773856285 cites W2101842666 @default.
• W2773856285 cites W2102647393 @default.
• W2773856285 cites W2110474289 @default.
• W2773856285 cites W2128629219 @default.
• W2773856285 cites W2132302780 @default.
• W2773856285 cites W2142427646 @default.
• W2773856285 cites W2155391879 @default.
• W2773856285 cites W2463323547 @default.
• W2773856285 cites W2662679145 @default.
• W2773856285 doi "https://doi.org/10.1016/j.biopha.2017.10.139" @default.
• W2773856285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29793326" @default.
• W2773856285 hasPublicationYear "2018" @default.
• W2773856285 type Work @default.
• W2773856285 sameAs 2773856285 @default.
• W2773856285 citedByCount "20" @default.
• W2773856285 countsByYear W27738562852018 @default.
• W2773856285 countsByYear W27738562852019 @default.
• W2773856285 countsByYear W27738562852020 @default.
• W2773856285 countsByYear W27738562852021 @default.
• W2773856285 countsByYear W27738562852022 @default.
• W2773856285 countsByYear W27738562852023 @default.
• W2773856285 crossrefType "journal-article" @default.
• W2773856285 hasAuthorship W2773856285A5003355798 @default.
• W2773856285 hasAuthorship W2773856285A5007067761 @default.
• W2773856285 hasAuthorship W2773856285A5028912813 @default.
• W2773856285 hasAuthorship W2773856285A5034306021 @default.
• W2773856285 hasAuthorship W2773856285A5047388991 @default.
• W2773856285 hasAuthorship W2773856285A5058306320 @default.
• W2773856285 hasAuthorship W2773856285A5066716873 @default.
• W2773856285 hasAuthorship W2773856285A5083896582 @default.
• W2773856285 hasBestOaLocation W27738562851 @default.
• W2773856285 hasConcept C104317684 @default.
• W2773856285 hasConcept C126322002 @default.
• W2773856285 hasConcept C134018914 @default.
• W2773856285 hasConcept C149011108 @default.
• W2773856285 hasConcept C2777704780 @default.
• W2773856285 hasConcept C2778163477 @default.
• W2773856285 hasConcept C2779091943 @default.
• W2773856285 hasConcept C2779134260 @default.
• W2773856285 hasConcept C2780072125 @default.
• W2773856285 hasConcept C43554185 @default.
• W2773856285 hasConcept C4733338 @default.
• W2773856285 hasConcept C55493867 @default.
• W2773856285 hasConcept C555293320 @default.
• W2773856285 hasConcept C57089818 @default.
• W2773856285 hasConcept C62746215 @default.
• W2773856285 hasConcept C63932345 @default.
• W2773856285 hasConcept C71924100 @default.
• W2773856285 hasConcept C76591681 @default.
• W2773856285 hasConcept C86339819 @default.
• W2773856285 hasConcept C86803240 @default.
• W2773856285 hasConceptScore W2773856285C104317684 @default.
• W2773856285 hasConceptScore W2773856285C126322002 @default.
• W2773856285 hasConceptScore W2773856285C134018914 @default.
• W2773856285 hasConceptScore W2773856285C149011108 @default.
• W2773856285 hasConceptScore W2773856285C2777704780 @default.
• W2773856285 hasConceptScore W2773856285C2778163477 @default.
• W2773856285 hasConceptScore W2773856285C2779091943 @default.
• W2773856285 hasConceptScore W2773856285C2779134260 @default.
• W2773856285 hasConceptScore W2773856285C2780072125 @default.
• W2773856285 hasConceptScore W2773856285C43554185 @default.
• W2773856285 hasConceptScore W2773856285C4733338 @default.
• W2773856285 hasConceptScore W2773856285C55493867 @default.
• W2773856285 hasConceptScore W2773856285C555293320 @default.
• W2773856285 hasConceptScore W2773856285C57089818 @default.
• W2773856285 hasConceptScore W2773856285C62746215 @default.
• W2773856285 hasConceptScore W2773856285C63932345 @default.
• W2773856285 hasConceptScore W2773856285C71924100 @default.
• W2773856285 hasConceptScore W2773856285C76591681 @default.
• W2773856285 hasConceptScore W2773856285C86339819 @default.

• next