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• W2773888891 abstract "Abstract Carboplatin, a second-generation platinum agent, has been used as a cancer therapy for decades and exhibits strong anti-tumor activity. However, the wide application of carboplatin is largely limited due to its side effects, especially myelosuppression. Here, we combined carboplatin with curcumin, a natural product that improves tumor-induced anemia, for the treatment of fibrosarcoma to improve the side effects of carboplatin. We first examined the synergistic and attenuated effects of the two agents in a T241-bearing mouse model. The combination therapy caused no obvious synergistic effect, but curcumin significantly improved the survival rate of carboplatin-treated mice. Histologic analysis of the kidney and bone marrow revealed that curcumin improved carboplatin-induced myelosuppression but did not affect the kidney. To determine the mechanism involved, we introduced a probe derived from curcumin to identify its targets in bone marrow cells and the results provided us a clue that curcumin might affect the DNA repair pathway. Western blot analysis revealed that curcumin up-regulated BRCA1, BRCA2 and ERCC1 expression in bone marrow. In conclusion, curcumin attenuates carboplatin-induced myelosuppression by activating the DNA repair pathway in bone marrow cells." @default.
• W2773888891 created "2017-12-22" @default.
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• W2773888891 date "2017-12-18" @default.
• W2773888891 modified "2023-10-10" @default.
• W2773888891 title "Curcumin activates DNA repair pathway in bone marrow to improve carboplatin-induced myelosuppression" @default.
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• W2773888891 doi "https://doi.org/10.1038/s41598-017-16436-9" @default.
• W2773888891 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5735145" @default.
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• W2773888891 hasPublicationYear "2017" @default.
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