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• W277394557 abstract "Research Article1 March 1987free access Glucocorticoid induction of the rat tryptophan oxygenase gene is mediated by two widely separated glucocorticoid-responsive elements. U. Danesch U. Danesch Search for more papers by this author B. Gloss B. Gloss Search for more papers by this author W. Schmid W. Schmid Search for more papers by this author G. Schütz G. Schütz Search for more papers by this author R. Schüle R. Schüle Search for more papers by this author R. Renkawitz R. Renkawitz Search for more papers by this author U. Danesch U. Danesch Search for more papers by this author B. Gloss B. Gloss Search for more papers by this author W. Schmid W. Schmid Search for more papers by this author G. Schütz G. Schütz Search for more papers by this author R. Schüle R. Schüle Search for more papers by this author R. Renkawitz R. Renkawitz Search for more papers by this author Author Information U. Danesch, B. Gloss, W. Schmid, G. Schütz, R. Schüle and R. Renkawitz The EMBO Journal (1987)6:625-630https://doi.org/10.1002/j.1460-2075.1987.tb04800.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Transcription of the gene coding for tryptophan oxygenase (TO) in rat liver is induced 10-fold by glucocorticoids. To identify DNA elements mediating the glucocorticoid-regulated expression of the TO gene we transfected mouse L cells with a fusion gene consisting of 1.95 kb TO 5′-flanking sequences linked to the coding sequence of the gene for chloramphenicol acetyltransferase (CAT). CAT assay and RNA mapping experiments demonstrate that both transient and stable expression of the TO-CAT fusion gene are inducible by dexamethasone. Analysis of transcripts from 5′-deletion mutants identifies two glucocorticoid-responsive elements (GRE), located 450 bp and 1.2 kb upstream of the cap site. The purified rat glucocorticoid receptor binds to the sequence of each GRE as evidenced from footprinting experiments. Interestingly the protected sequence of the proximal footprint is by itself not sufficient for sequence induction, but requires sequences located immediately upstream. Previous ArticleNext Article Volume 6Issue 31 March 1987In this issue RelatedDetailsLoading ..." @default.
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• W277394557 date "1987-03-01" @default.
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• W277394557 title "Glucocorticoid induction of the rat tryptophan oxygenase gene is mediated by two widely separated glucocorticoid-responsive elements." @default.
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• W277394557 doi "https://doi.org/10.1002/j.1460-2075.1987.tb04800.x" @default.
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