FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2773974606> ?p ?o ?g. }

• W2773974606 endingPage "137" @default.
• W2773974606 startingPage "136" @default.
• W2773974606 abstract "Background: OPTN policy permits both kidneys to be allocated to the same patient if at least two of the following donor criteria are met: age>60, eCrCl<65 ml/min based on admission creatinine (Cr), rising Cr (>2.5mg/dl), longstanding hypertension or diabetes, 15%<glomerulosclerosis<50%. The OPTN Kidney Transplantation Committee (KTC) is evaluating data to assess whether changes to this policy would help increase organ utilization. Methods: Cox models for graft survival adjusting for log(KDRI), recip age, diabetes status, and procedure type (single vs. dual) were estimated using solitary, primary, adult, deceased donor kidney recipients from 2000-2007 per the OPTN database. Organ allocation and disposition data from 2012 were also assessed. (En bloc tx were analyzed separately but not included here.) Results: In 2012, OPOs reported that only 207 (3%) kidney donors were eligible for dual allocation under current policy, and only 87 dual tx occurred. The frequency of dual tx has decreased in recent years (170 were performed in 2005). Yet dual tx confers substantially lower risk of graft failure (HR=0.82, p<0.001), with an improved survival most pronounced for high KDPI kidneys.Figure: No Caption available.Of the 2,759 kidneys discarded in 2012, 2,126 (77%) were recovered from the same donor. Of these, 1,004 were from the same KDPI>85% donor. While relatively few of the 1,004 were reported discarded due to anatomical abnormalities (6%), diseased organ (4%), vascular damage (1%), organ trauma (1%), or infection (0%), more than two thirds were discarded due to “biopsy findings” (42%) or “list exhausted” (26%). Conclusions: These results show that dual tx appears to lessen the detrimental effect of high KDPI and that more opportunities for dual tx may exist than are currently being realized. The KTC is evaluating whether revisions to policy (e.g., basing dual eligibility on KDPI) and the match system (e.g., allowing offer screening based on single vs. dual) are needed to encourage the dual use of kidneys that confer a survival benefit over dialysis but would otherwise be discarded." @default.
• W2773974606 created "2017-12-22" @default.
• W2773974606 creator A5000192055 @default.
• W2773974606 creator A5006695209 @default.
• W2773974606 creator A5007217229 @default.
• W2773974606 creator A5045062801 @default.
• W2773974606 creator A5052478252 @default.
• W2773974606 creator A5063486441 @default.
• W2773974606 date "2014-07-01" @default.
• W2773974606 modified "2023-09-26" @default.
• W2773974606 title "Two High KDPI Kidneys Are Better Than One: Opportunities to Expand Dual Kidney Transplantation to Reduce Discard Rates." @default.
• W2773974606 doi "https://doi.org/10.1097/00007890-201407151-00420" @default.
• W2773974606 hasPublicationYear "2014" @default.
• W2773974606 type Work @default.
• W2773974606 sameAs 2773974606 @default.
• W2773974606 citedByCount "0" @default.
• W2773974606 crossrefType "journal-article" @default.
• W2773974606 hasAuthorship W2773974606A5000192055 @default.
• W2773974606 hasAuthorship W2773974606A5006695209 @default.
• W2773974606 hasAuthorship W2773974606A5007217229 @default.
• W2773974606 hasAuthorship W2773974606A5045062801 @default.
• W2773974606 hasAuthorship W2773974606A5052478252 @default.
• W2773974606 hasAuthorship W2773974606A5063486441 @default.
• W2773974606 hasBestOaLocation W27739746061 @default.
• W2773974606 hasConcept C126322002 @default.
• W2773974606 hasConcept C126894567 @default.
• W2773974606 hasConcept C134018914 @default.
• W2773974606 hasConcept C141071460 @default.
• W2773974606 hasConcept C2777390665 @default.
• W2773974606 hasConcept C2779561371 @default.
• W2773974606 hasConcept C2780091579 @default.
• W2773974606 hasConcept C2780306776 @default.
• W2773974606 hasConcept C2911091166 @default.
• W2773974606 hasConcept C555293320 @default.
• W2773974606 hasConcept C71924100 @default.
• W2773974606 hasConceptScore W2773974606C126322002 @default.
• W2773974606 hasConceptScore W2773974606C126894567 @default.
• W2773974606 hasConceptScore W2773974606C134018914 @default.
• W2773974606 hasConceptScore W2773974606C141071460 @default.
• W2773974606 hasConceptScore W2773974606C2777390665 @default.
• W2773974606 hasConceptScore W2773974606C2779561371 @default.
• W2773974606 hasConceptScore W2773974606C2780091579 @default.
• W2773974606 hasConceptScore W2773974606C2780306776 @default.
• W2773974606 hasConceptScore W2773974606C2911091166 @default.
• W2773974606 hasConceptScore W2773974606C555293320 @default.
• W2773974606 hasConceptScore W2773974606C71924100 @default.
• W2773974606 hasLocation W27739746061 @default.
• W2773974606 hasLocation W27739746062 @default.
• W2773974606 hasOpenAccess W2773974606 @default.
• W2773974606 hasPrimaryLocation W27739746061 @default.
• W2773974606 hasRelatedWork W1486584413 @default.
• W2773974606 hasRelatedWork W1992089635 @default.
• W2773974606 hasRelatedWork W2047967234 @default.
• W2773974606 hasRelatedWork W2087086071 @default.
• W2773974606 hasRelatedWork W2117376546 @default.
• W2773974606 hasRelatedWork W2135058494 @default.
• W2773974606 hasRelatedWork W2348429519 @default.
• W2773974606 hasRelatedWork W2371369831 @default.
• W2773974606 hasRelatedWork W3033405197 @default.
• W2773974606 hasRelatedWork W3117361317 @default.
• W2773974606 hasVolume "98" @default.
• W2773974606 isParatext "false" @default.
• W2773974606 isRetracted "false" @default.
• W2773974606 magId "2773974606" @default.
• W2773974606 workType "article" @default.