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- W2774115170 abstract "A Michael–hemiketalization–oxa-Pictet–Spengler cyclization has been developed for the construction of chiral bridged and spiro heterocyclic skeletons with one spiro stereogenic carbon center and two bridgehead carbon centers, utilizing cooperative catalysts of a Takemoto thiourea catalyst and a triflimide. In particular, an oxocarbenium ion acts as a key intermediate for this cyclization reaction. Additionally, biological evaluation of this type of novel structure has revealed obvious antiproliferative activity against some cancer cell lines." @default.
- W2774115170 created "2017-12-22" @default.
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- W2774115170 date "2017-12-01" @default.
- W2774115170 modified "2023-09-30" @default.
- W2774115170 title "Organo-Catalyzed Asymmetric Michael–Hemiketalization–Oxa-Pictet–Spengler Cyclization for Bridged and Spiro Heterocyclic Skeletons: Oxocarbenium Ion as a Key Intermediate" @default.
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- W2774115170 doi "https://doi.org/10.1021/acs.orglett.7b03341" @default.
- W2774115170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29192792" @default.
- W2774115170 hasPublicationYear "2017" @default.
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