Matches in SemOpenAlex for { <https://semopenalex.org/work/W2774142922> ?p ?o ?g. }
- W2774142922 abstract "Dendritic cells (DCs) are specialized immune cells that scan peripheral tissues for foreign material or aberrant cells and, upon recognition of such danger signals, travel to lymph nodes to activate T cells and evoke an immune response. For this, DCs travel large distances through the body, encountering a variety of microenvironments with different mechanical properties such as tissue stiffness. While immune-related pathological conditions such as fibrosis or cancer are associated with tissue stiffening, the role of tissue stiffness in regulating key functions of DCs has not been studied yet. Here, we investigated the effect of substrate stiffness on the phenotype and function of DCs by conditioning DCs on polyacrylamide substrates of 2, 12 and 50 kPa. Interestingly, we found that C-type lectin expression on immature DCs (iDCs) is regulated by substrate stiffness, resulting in differential antigen internalization. Furthermore, we show that substrate stiffness affects β2 integrin expression and podosome formation by iDCs. Finally, we demonstrate that substrate stiffness influences CD83 and CCR7 expression on mature DCs, the latter leading to altered chemokine-directed migration. Together, our results indicate that DC phenotype and function are affected by substrate stiffness, suggesting that tissue stiffness is an important determinant for modulating immune responses." @default.
- W2774142922 created "2017-12-22" @default.
- W2774142922 creator A5003964196 @default.
- W2774142922 creator A5041824888 @default.
- W2774142922 creator A5045102938 @default.
- W2774142922 creator A5054940822 @default.
- W2774142922 creator A5065173194 @default.
- W2774142922 creator A5069988691 @default.
- W2774142922 date "2017-12-13" @default.
- W2774142922 modified "2023-10-16" @default.
- W2774142922 title "Substrate stiffness influences phenotype and function of human antigen-presenting dendritic cells" @default.
- W2774142922 cites W1867960490 @default.
- W2774142922 cites W1967538535 @default.
- W2774142922 cites W1976709402 @default.
- W2774142922 cites W1980934196 @default.
- W2774142922 cites W1997322465 @default.
- W2774142922 cites W2003042213 @default.
- W2774142922 cites W2004037261 @default.
- W2774142922 cites W2006637623 @default.
- W2774142922 cites W2019284238 @default.
- W2774142922 cites W2019979937 @default.
- W2774142922 cites W2024250498 @default.
- W2774142922 cites W2027498662 @default.
- W2774142922 cites W2034803034 @default.
- W2774142922 cites W2040466546 @default.
- W2774142922 cites W2042442023 @default.
- W2774142922 cites W2044754255 @default.
- W2774142922 cites W2046913258 @default.
- W2774142922 cites W2053757111 @default.
- W2774142922 cites W2062461864 @default.
- W2774142922 cites W2086244192 @default.
- W2774142922 cites W2087166273 @default.
- W2774142922 cites W2087841556 @default.
- W2774142922 cites W2095301611 @default.
- W2774142922 cites W2096757412 @default.
- W2774142922 cites W2099060728 @default.
- W2774142922 cites W2100303404 @default.
- W2774142922 cites W2103883318 @default.
- W2774142922 cites W2104401785 @default.
- W2774142922 cites W2106829507 @default.
- W2774142922 cites W2111170139 @default.
- W2774142922 cites W2115124692 @default.
- W2774142922 cites W2124270882 @default.
- W2774142922 cites W2125064243 @default.
- W2774142922 cites W2131537135 @default.
- W2774142922 cites W2134208433 @default.
- W2774142922 cites W2141768942 @default.
- W2774142922 cites W2146455279 @default.
- W2774142922 cites W2147621714 @default.
- W2774142922 cites W2148328620 @default.
- W2774142922 cites W2155493718 @default.
- W2774142922 cites W2159731793 @default.
- W2774142922 cites W2169528038 @default.
- W2774142922 cites W2170240282 @default.
- W2774142922 cites W2176251527 @default.
- W2774142922 cites W2233811110 @default.
- W2774142922 cites W2254613643 @default.
- W2774142922 cites W2267284177 @default.
- W2774142922 cites W2271515476 @default.
- W2774142922 cites W2466302149 @default.
- W2774142922 cites W2467077417 @default.
- W2774142922 cites W2476542314 @default.
- W2774142922 cites W2606851967 @default.
- W2774142922 cites W2734148025 @default.
- W2774142922 cites W3021508179 @default.
- W2774142922 cites W92010875 @default.
- W2774142922 doi "https://doi.org/10.1038/s41598-017-17787-z" @default.
- W2774142922 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5727489" @default.
- W2774142922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29235514" @default.
- W2774142922 hasPublicationYear "2017" @default.
- W2774142922 type Work @default.
- W2774142922 sameAs 2774142922 @default.
- W2774142922 citedByCount "62" @default.
- W2774142922 countsByYear W27741429222018 @default.
- W2774142922 countsByYear W27741429222019 @default.
- W2774142922 countsByYear W27741429222020 @default.
- W2774142922 countsByYear W27741429222021 @default.
- W2774142922 countsByYear W27741429222022 @default.
- W2774142922 countsByYear W27741429222023 @default.
- W2774142922 crossrefType "journal-article" @default.
- W2774142922 hasAuthorship W2774142922A5003964196 @default.
- W2774142922 hasAuthorship W2774142922A5041824888 @default.
- W2774142922 hasAuthorship W2774142922A5045102938 @default.
- W2774142922 hasAuthorship W2774142922A5054940822 @default.
- W2774142922 hasAuthorship W2774142922A5065173194 @default.
- W2774142922 hasAuthorship W2774142922A5069988691 @default.
- W2774142922 hasBestOaLocation W27741429221 @default.
- W2774142922 hasConcept C104317684 @default.
- W2774142922 hasConcept C127716648 @default.
- W2774142922 hasConcept C127801297 @default.
- W2774142922 hasConcept C12823836 @default.
- W2774142922 hasConcept C13373296 @default.
- W2774142922 hasConcept C139770010 @default.
- W2774142922 hasConcept C1491633281 @default.
- W2774142922 hasConcept C159985019 @default.
- W2774142922 hasConcept C185592680 @default.
- W2774142922 hasConcept C192562407 @default.
- W2774142922 hasConcept C203014093 @default.
- W2774142922 hasConcept C2779372316 @default.
- W2774142922 hasConcept C54355233 @default.