Matches in SemOpenAlex for { <https://semopenalex.org/work/W2774158637> ?p ?o ?g. }
- W2774158637 endingPage "31" @default.
- W2774158637 startingPage "25" @default.
- W2774158637 abstract "The application of nanocarrier aqueous suspensions as drug delivery systems offers an important challenge for formulators: their reduced physicochemical stability during storage. Here, a novel approach to produce dry redispersible nanocapsules by fluid bed granulation intended for oral administration is proposed. In addition, the influence of the cationic coating of nanoparticles on the properties of granules was evaluated. Lipid-core nanocapsules were prepared in aqueous dispersion with or without a cationic coating by chitosan to be used as the granulating liquid in the fluid bed granulation process. Granule properties, like volume-based mean particle size, yield, moisture content, morphological characteristics, flow properties, and redispersion behavior were evaluated. The granulation process had a yield close to 90%, affording granules with moisture content lower than 4% and good flow properties. Nanocapsules adhered to the surface of the primary particles which agglomerating to form the granules, but were released upon redispersion in water. Moreover, cationic coating of the nanocapsules improved the aqueous redispersion behavior of granules. In conclusion, this novel approach to produce granules as an intermediate or final dosage form by fluid bed granulation represents an innovative process to develop new oral nanomedicines. Furthermore, the cationic coating of nanocapsules has an important role on the aqueous redispersion properties of these granules." @default.
- W2774158637 created "2017-12-22" @default.
- W2774158637 creator A5001329248 @default.
- W2774158637 creator A5006489221 @default.
- W2774158637 creator A5011836091 @default.
- W2774158637 creator A5012519379 @default.
- W2774158637 creator A5014985678 @default.
- W2774158637 creator A5034472840 @default.
- W2774158637 date "2018-02-01" @default.
- W2774158637 modified "2023-10-16" @default.
- W2774158637 title "Fluid bed granulation as an innovative process to produce dry redispersible nanocapsules: Influence of cationic coating of particles" @default.
- W2774158637 cites W1968948171 @default.
- W2774158637 cites W1969047331 @default.
- W2774158637 cites W1976354109 @default.
- W2774158637 cites W1984899361 @default.
- W2774158637 cites W1992085698 @default.
- W2774158637 cites W2005876932 @default.
- W2774158637 cites W2006674242 @default.
- W2774158637 cites W2007307667 @default.
- W2774158637 cites W2008082604 @default.
- W2774158637 cites W2014816932 @default.
- W2774158637 cites W2029193570 @default.
- W2774158637 cites W2030423127 @default.
- W2774158637 cites W2033911789 @default.
- W2774158637 cites W2034187498 @default.
- W2774158637 cites W2036207528 @default.
- W2774158637 cites W2044019713 @default.
- W2774158637 cites W2047135654 @default.
- W2774158637 cites W2048456835 @default.
- W2774158637 cites W2053030235 @default.
- W2774158637 cites W2053162638 @default.
- W2774158637 cites W2055633868 @default.
- W2774158637 cites W2057153276 @default.
- W2774158637 cites W2060449522 @default.
- W2774158637 cites W2071688289 @default.
- W2774158637 cites W2072350223 @default.
- W2774158637 cites W2088142339 @default.
- W2774158637 cites W2096913455 @default.
- W2774158637 cites W2098700302 @default.
- W2774158637 cites W2103293895 @default.
- W2774158637 cites W2120826143 @default.
- W2774158637 cites W2121018584 @default.
- W2774158637 cites W2131648561 @default.
- W2774158637 cites W2140383918 @default.
- W2774158637 cites W2144907950 @default.
- W2774158637 cites W2162136831 @default.
- W2774158637 cites W2209174579 @default.
- W2774158637 cites W2315453258 @default.
- W2774158637 cites W2316829396 @default.
- W2774158637 cites W2317621174 @default.
- W2774158637 cites W2319617833 @default.
- W2774158637 cites W2324895622 @default.
- W2774158637 cites W2527670562 @default.
- W2774158637 doi "https://doi.org/10.1016/j.powtec.2017.12.048" @default.
- W2774158637 hasPublicationYear "2018" @default.
- W2774158637 type Work @default.
- W2774158637 sameAs 2774158637 @default.
- W2774158637 citedByCount "5" @default.
- W2774158637 countsByYear W27741586372020 @default.
- W2774158637 countsByYear W27741586372021 @default.
- W2774158637 countsByYear W27741586372023 @default.
- W2774158637 crossrefType "journal-article" @default.
- W2774158637 hasAuthorship W2774158637A5001329248 @default.
- W2774158637 hasAuthorship W2774158637A5006489221 @default.
- W2774158637 hasAuthorship W2774158637A5011836091 @default.
- W2774158637 hasAuthorship W2774158637A5012519379 @default.
- W2774158637 hasAuthorship W2774158637A5014985678 @default.
- W2774158637 hasAuthorship W2774158637A5034472840 @default.
- W2774158637 hasConcept C127413603 @default.
- W2774158637 hasConcept C155672457 @default.
- W2774158637 hasConcept C159985019 @default.
- W2774158637 hasConcept C171250308 @default.
- W2774158637 hasConcept C178790620 @default.
- W2774158637 hasConcept C183882617 @default.
- W2774158637 hasConcept C184651966 @default.
- W2774158637 hasConcept C185592680 @default.
- W2774158637 hasConcept C188027245 @default.
- W2774158637 hasConcept C192562407 @default.
- W2774158637 hasConcept C204399865 @default.
- W2774158637 hasConcept C2777968448 @default.
- W2774158637 hasConcept C2779251873 @default.
- W2774158637 hasConcept C2781448156 @default.
- W2774158637 hasConcept C42360764 @default.
- W2774158637 hasConcept C43617362 @default.
- W2774158637 hasConcept C49760210 @default.
- W2774158637 hasConcept C88463166 @default.
- W2774158637 hasConceptScore W2774158637C127413603 @default.
- W2774158637 hasConceptScore W2774158637C155672457 @default.
- W2774158637 hasConceptScore W2774158637C159985019 @default.
- W2774158637 hasConceptScore W2774158637C171250308 @default.
- W2774158637 hasConceptScore W2774158637C178790620 @default.
- W2774158637 hasConceptScore W2774158637C183882617 @default.
- W2774158637 hasConceptScore W2774158637C184651966 @default.
- W2774158637 hasConceptScore W2774158637C185592680 @default.
- W2774158637 hasConceptScore W2774158637C188027245 @default.
- W2774158637 hasConceptScore W2774158637C192562407 @default.
- W2774158637 hasConceptScore W2774158637C204399865 @default.
- W2774158637 hasConceptScore W2774158637C2777968448 @default.