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- W2774174297 abstract "Summary Background Childhood obesity is a serious public health problem in Mexico. Adult gut microbiota composition has been linked to obesity, but few studies have addressed the role of gut microbiota in childhood obesity. Objectives The aim of this study is to compare gut microbiota composition in obese and normal‐weight children and to associate gut microbiota profiles with amino acid serum levels and obesity‐related metabolic traits. Methods Microbial taxa relative abundance was determined by 16S rRNA sequencing in 67 normal‐weight and 71 obese children aged 6–12 years. Serum amino acid levels were measured by mass spectrometry. Associations between microbiota composition, metabolic parameters and amino acid serum levels were tested. Results No significant differences in phyla abundances or Firmicutes / Bacteroidetes ratios were observed between normal‐weight and obese children. However, Bacteroides eggerthii abundance was significantly higher in obese children and correlated positively with body fat percentage and negatively with insoluble fibre intake. Additionally, Bacteroides plebeius and unclassified Christensenellaceae abundances were significantly higher in normal‐weight children. Abundance of both these species correlated negatively with phenylalanine serum levels, a metabolite also found to be associated with obesity in Mexican children. Conclusions The study identified bacterial species associated with obesity, metabolic complications and amino acid serum levels in Mexican children." @default.
- W2774174297 created "2017-12-22" @default.
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- W2774174297 date "2017-12-05" @default.
- W2774174297 modified "2023-10-18" @default.
- W2774174297 title "Composition of gut microbiota in obese and normal-weight Mexican school-age children and its association with metabolic traits" @default.
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- W2774174297 doi "https://doi.org/10.1111/ijpo.12262" @default.
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