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- W2774329752 abstract "Cellular zinc (Zn(ii)) is bound with proteins that are part of the proteomes of all domains of life. It is mostly utilized as a catalytic or structural protein cofactor, which results in a vast number of binding architectures. The Zn(ii) ion is also important for the formation of transient protein complexes with a Zn(ii)-dependent quaternary structure that is formed upon cellular zinc signals. The mechanisms by which proteins associate with and dissociate from Zn(ii) and the connection with cellular Zn(ii) changes remain incompletely understood. In this study, we aimed to examine how zinc protein domains with various Zn(ii)-binding architectures are formed under free Zn(ii) concentration changes and how formation of the Zn(ii)-dependent assemblies is related to the protein concentration and reactivity. To accomplish these goals we chose four zinc domains with different Zn(ii)-to-protein binding stoichiometries: classical zinc finger (ZnP), LIM domain (Zn2P), zinc hook (ZnP2) and zinc clasp (ZnP1P2) folds. Our research demonstrated a lack of changes in the saturation level of intraprotein zinc binding sites, despite various peptide concentrations, while homo- and heterodimers indicated a concentration-dependent tendency. In other words, at a certain free Zn(ii) concentration, the fraction of a formed dimeric complex increases or decreases with subunit concentration changes. Secondly, even small or local changes in free Zn(ii) may significantly affect protein saturation depending on its architecture, function and subcellular concentration. In our paper, we indicate the importance of interdependence of free Zn(ii) availability and protein subunit concentrations for cellular zinc signal regulation." @default.
- W2774329752 created "2017-12-22" @default.
- W2774329752 creator A5014617639 @default.
- W2774329752 creator A5040649064 @default.
- W2774329752 creator A5081178130 @default.
- W2774329752 date "2018-01-01" @default.
- W2774329752 modified "2023-10-03" @default.
- W2774329752 title "Interdependence of free zinc changes and protein complex assembly – insights into zinc signal regulation" @default.
- W2774329752 cites W1021402973 @default.
- W2774329752 cites W1509086826 @default.
- W2774329752 cites W1531010890 @default.
- W2774329752 cites W1564861448 @default.
- W2774329752 cites W1685907241 @default.
- W2774329752 cites W1841539097 @default.
- W2774329752 cites W1851565937 @default.
- W2774329752 cites W1943629100 @default.
- W2774329752 cites W1967735305 @default.
- W2774329752 cites W1971861118 @default.
- W2774329752 cites W1972992920 @default.
- W2774329752 cites W1974830912 @default.
- W2774329752 cites W1978298108 @default.
- W2774329752 cites W1979100273 @default.
- W2774329752 cites W1986171863 @default.
- W2774329752 cites W1992240624 @default.
- W2774329752 cites W1996880521 @default.
- W2774329752 cites W2002886146 @default.
- W2774329752 cites W2003049033 @default.
- W2774329752 cites W2003394120 @default.
- W2774329752 cites W2007595454 @default.
- W2774329752 cites W2010174774 @default.
- W2774329752 cites W2010338437 @default.
- W2774329752 cites W2013947447 @default.
- W2774329752 cites W2019828928 @default.
- W2774329752 cites W2023256273 @default.
- W2774329752 cites W2031255224 @default.
- W2774329752 cites W2032977054 @default.
- W2774329752 cites W2035585204 @default.
- W2774329752 cites W2038443140 @default.
- W2774329752 cites W2040838669 @default.
- W2774329752 cites W2043986265 @default.
- W2774329752 cites W2048094630 @default.
- W2774329752 cites W2050551315 @default.
- W2774329752 cites W2057551117 @default.
- W2774329752 cites W2060893933 @default.
- W2774329752 cites W2061629679 @default.
- W2774329752 cites W2062110035 @default.
- W2774329752 cites W2063635739 @default.
- W2774329752 cites W2063755536 @default.
- W2774329752 cites W2065886456 @default.
- W2774329752 cites W2066161887 @default.
- W2774329752 cites W2068656291 @default.
- W2774329752 cites W2071222048 @default.
- W2774329752 cites W2072659663 @default.
- W2774329752 cites W2077298431 @default.
- W2774329752 cites W2077684653 @default.
- W2774329752 cites W2081607061 @default.
- W2774329752 cites W2087245452 @default.
- W2774329752 cites W2091060631 @default.
- W2774329752 cites W2097951289 @default.
- W2774329752 cites W2098822872 @default.
- W2774329752 cites W2098866409 @default.
- W2774329752 cites W2103688326 @default.
- W2774329752 cites W2107251417 @default.
- W2774329752 cites W2110383903 @default.
- W2774329752 cites W2116477640 @default.
- W2774329752 cites W2116727358 @default.
- W2774329752 cites W2118296350 @default.
- W2774329752 cites W2123184604 @default.
- W2774329752 cites W2125537942 @default.
- W2774329752 cites W2128934600 @default.
- W2774329752 cites W2137986227 @default.
- W2774329752 cites W2138193344 @default.
- W2774329752 cites W2143843694 @default.
- W2774329752 cites W2150583375 @default.
- W2774329752 cites W2153776282 @default.
- W2774329752 cites W2159554322 @default.
- W2774329752 cites W2160194356 @default.
- W2774329752 cites W2162184782 @default.
- W2774329752 cites W2164258188 @default.
- W2774329752 cites W2171749710 @default.
- W2774329752 cites W2305979891 @default.
- W2774329752 cites W2329823705 @default.
- W2774329752 cites W2344658806 @default.
- W2774329752 cites W2415537956 @default.
- W2774329752 cites W2416705150 @default.
- W2774329752 cites W2419493465 @default.
- W2774329752 cites W2419532700 @default.
- W2774329752 cites W2464993195 @default.
- W2774329752 cites W2547643386 @default.
- W2774329752 cites W2583003623 @default.
- W2774329752 cites W2623016513 @default.
- W2774329752 cites W2750045700 @default.
- W2774329752 doi "https://doi.org/10.1039/c7mt00301c" @default.
- W2774329752 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29240217" @default.
- W2774329752 hasPublicationYear "2018" @default.
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