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• W2774348337 abstract "Objective: The potential of magnetic resonance imaging (MRI) as a technical biomarker for cerebral microstructural alterations in neurodegenerative diseases is under investigation. In this study, a framework for the longitudinal analysis of diffusion tensor imaging (DTI)-based mapping was applied to the assessment of predefined white matter tracts in amyotrophic lateral sclerosis (ALS), as an example for a rapid progressive neurodegenerative disease. Methods: DTI was performed every three months in six patients with ALS (mean(M)= 7.7; range 3 to15 scans) and in six controls (M= 3; range 2 to 5 scans) with the identical scanning protocol, resulting in a total of 65 longitudinal DTI datasets. Fractional anisotropy (FA), mean diffusivity (MD), axonal diffusivity (AD), radial diffusivity (RD), and the ratio AD/RD were studied to analyse alterations within the corticospinal tract (CST) which is a prominently affected tract structure in ALS and the tract correlating with Braak`s neuropathological stage 1. A correlation analysis was performed between progression rates based on DTI metrics and the revised ALS functional rating scale (ALS-FRS-R). Results: Patients with ALS showed an FA and AD/RD decline along the CST, while DTI metrics of controls did not change in longitudinal DTI scans. The FA and AD/RD decrease progression correlated significantly with ALS-FRS-R decrease progression. Conclusion: On the basis of the longitudinal assessment, DTI-based metrics can be considered as a possible noninvasive follow-up marker for disease progression in neurodegeneration. This finding was demonstrated here for ALS as a fast progressing neurodegenerative disease." @default.
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• W2774348337 date "2017-12-05" @default.
• W2774348337 modified "2023-09-25" @default.
• W2774348337 title "Longitudinal Diffusion Tensor Imaging-Based Assessment of Tract Alterations: An Application to Amyotrophic Lateral Sclerosis" @default.
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• W2774348337 doi "https://doi.org/10.3389/fnhum.2017.00567" @default.
• W2774348337 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5723297" @default.
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