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• W2774348538 abstract "ABSTRACT The purpose of this study was to develop a magnetic resonance T 2 * relaxometry‐based multiple linear regression model to predict the structural properties of the healing anterior cruciate ligament (ACL) over a 24‐week healing period following ACL repair in Yucatan minipigs. Two hypotheses were tested: (i) that a regression model based on ACL sub‐volumes containing short and long T 2 * relaxation times would outperform a competing model based on sub‐volumes of short T 2 * relaxation times only; and (ii) that an optimized regression model would be capable of predicting ACL structural properties between 6 and 24 weeks post‐repair. ACLs were imaged in 24 minipigs (8/group) at either 6, 12, or 24 weeks after ACL repair. The structural properties of the ACLs were determined from tensile failure tests. Four multiple linear regression models of increasing complexity were fitted to the data. Akaike Information Criterion values and Bland–Altman tests were used to compare model performance and to test the hypotheses. The structural properties predicted from the multiple linear regression model that was based on the change in ACL sub‐volumes of both the short and long T 2 * relaxation times over the healing period were in closest agreement to the measured values, suggesting that the amounts of both organized and disorganized collagen, and the change in these quantities over time, are required to predict the structural properties of healing ACLs accurately. Clinical significance: our time‐specific, T 2 *‐based regression model may allow us to estimate the structural properties of ACL repairs in vivo longitudinally. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1701–1709, 2018." @default.
• W2774348538 created "2017-12-22" @default.
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• W2774348538 date "2017-12-29" @default.
• W2774348538 modified "2023-10-14" @default.
• W2774348538 title "Magnetic resonance measurements of tissue quantity and quality using T₂* relaxometry predict temporal changes in the biomechanical properties of the healing ACL" @default.
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• W2774348538 doi "https://doi.org/10.1002/jor.23830" @default.
• W2774348538 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5995620" @default.
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