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- W2774488891 abstract "A diffusely invasive nature is a major obstacle in treating a malignant brain tumor, diffuse glioma, which prevents neurooncologists from surgically removing the tumor cells even in combination with chemotherapy and radiation. Recently updated classification of diffuse gliomas based on distinct genetic and epigenetic features has culminated in a multilayered diagnostic approach to combine histologic phenotypes and molecular genotypes in an integrated diagnosis. However, it is still a work in progress to decipher how the genetic aberrations contribute to the aggressive nature of gliomas including their highly invasive capacity. Here we depict a set of recent discoveries involving molecular genetic determinants of the infiltrating nature of glioma cells, especially focusing on genetic mutations in receptor tyrosine kinase pathways and metabolic reprogramming downstream of common cancer mutations. The specific biology of glioma cell invasion provides an opportunity to explore the genotype-phenotype correlation in cancer and develop novel glioma-specific therapeutic strategies for this devastating disease." @default.
- W2774488891 created "2017-12-22" @default.
- W2774488891 creator A5005312770 @default.
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- W2774488891 creator A5058658201 @default.
- W2774488891 creator A5076853606 @default.
- W2774488891 date "2017-12-04" @default.
- W2774488891 modified "2023-10-16" @default.
- W2774488891 title "Molecular and Genetic Determinants of Glioma Cell Invasion" @default.
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- W2774488891 doi "https://doi.org/10.3390/ijms18122609" @default.
- W2774488891 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5751212" @default.
- W2774488891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29207533" @default.
- W2774488891 hasPublicationYear "2017" @default.
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