Matches in SemOpenAlex for { <https://semopenalex.org/work/W2774505979> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2774505979 abstract "Klotho is an anti-ageing gene belonging to the glycosidase family-1 of enzymes, whichhas been shown to reduce the rate of ageing, in mice, rats, zebrafish, and humans. Itacts at the organ as well as at the cellular level, to carry out this anti-ageing function. Atthe cellular level, it has been shown by overexpression studies that klotho is able tostrongly activate the Superoxide dismutase (SOD) mediated reactive oxygen species(ROS) scavenging pathway. Yet, whether this is a homeostatic function of klotho, is notknown. We investigated this function of klotho by subjecting HEK293 cells to ROSstress using physiologically observed levels of H2O2 and nicotine. Though low levels ofH2O2 stress did elicit activation of homeostatic pathways, physiological levels ofnicotine caused an overload of ROS which was too high to elicit a homeostaticresponse, as evinced by the measurement of ROS levels, using H2DCFDA. Further,measurement of klotho levels indicated that H2O2 caused its upregulation at very lowlevels, while even low levels of nicotine treatment led to a drastic decrease of klothoexpression. Thus, we can conclude that very low levels of ROS stress cause anupregulation of klotho expression and elicit a homeostatic response, while higher levelscause a decrease in its expression and are hence, unable to elicit a homeostaticresponse." @default.
- W2774505979 created "2017-12-22" @default.
- W2774505979 creator A5045477186 @default.
- W2774505979 creator A5086644694 @default.
- W2774505979 date "2017-04-01" @default.
- W2774505979 modified "2023-09-23" @default.
- W2774505979 title "Klotho: A Study of Oxidative Stress and Homeostasis" @default.
- W2774505979 hasPublicationYear "2017" @default.
- W2774505979 type Work @default.
- W2774505979 sameAs 2774505979 @default.
- W2774505979 citedByCount "0" @default.
- W2774505979 crossrefType "dissertation" @default.
- W2774505979 hasAuthorship W2774505979A5045477186 @default.
- W2774505979 hasAuthorship W2774505979A5086644694 @default.
- W2774505979 hasConcept C104317684 @default.
- W2774505979 hasConcept C126322002 @default.
- W2774505979 hasConcept C127561419 @default.
- W2774505979 hasConcept C134018914 @default.
- W2774505979 hasConcept C185592680 @default.
- W2774505979 hasConcept C2775838275 @default.
- W2774505979 hasConcept C2776151105 @default.
- W2774505979 hasConcept C2776878037 @default.
- W2774505979 hasConcept C2780091579 @default.
- W2774505979 hasConcept C48349386 @default.
- W2774505979 hasConcept C500499127 @default.
- W2774505979 hasConcept C55493867 @default.
- W2774505979 hasConcept C63645605 @default.
- W2774505979 hasConcept C71924100 @default.
- W2774505979 hasConcept C86803240 @default.
- W2774505979 hasConcept C95444343 @default.
- W2774505979 hasConcept C9832595 @default.
- W2774505979 hasConceptScore W2774505979C104317684 @default.
- W2774505979 hasConceptScore W2774505979C126322002 @default.
- W2774505979 hasConceptScore W2774505979C127561419 @default.
- W2774505979 hasConceptScore W2774505979C134018914 @default.
- W2774505979 hasConceptScore W2774505979C185592680 @default.
- W2774505979 hasConceptScore W2774505979C2775838275 @default.
- W2774505979 hasConceptScore W2774505979C2776151105 @default.
- W2774505979 hasConceptScore W2774505979C2776878037 @default.
- W2774505979 hasConceptScore W2774505979C2780091579 @default.
- W2774505979 hasConceptScore W2774505979C48349386 @default.
- W2774505979 hasConceptScore W2774505979C500499127 @default.
- W2774505979 hasConceptScore W2774505979C55493867 @default.
- W2774505979 hasConceptScore W2774505979C63645605 @default.
- W2774505979 hasConceptScore W2774505979C71924100 @default.
- W2774505979 hasConceptScore W2774505979C86803240 @default.
- W2774505979 hasConceptScore W2774505979C95444343 @default.
- W2774505979 hasConceptScore W2774505979C9832595 @default.
- W2774505979 hasLocation W27745059791 @default.
- W2774505979 hasOpenAccess W2774505979 @default.
- W2774505979 hasPrimaryLocation W27745059791 @default.
- W2774505979 hasRelatedWork W1537144565 @default.
- W2774505979 hasRelatedWork W164746271 @default.
- W2774505979 hasRelatedWork W2043158494 @default.
- W2774505979 hasRelatedWork W2049146584 @default.
- W2774505979 hasRelatedWork W2074043271 @default.
- W2774505979 hasRelatedWork W2079762333 @default.
- W2774505979 hasRelatedWork W2109042175 @default.
- W2774505979 hasRelatedWork W2120352051 @default.
- W2774505979 hasRelatedWork W2127962084 @default.
- W2774505979 hasRelatedWork W2244655601 @default.
- W2774505979 hasRelatedWork W2257331219 @default.
- W2774505979 hasRelatedWork W2502308186 @default.
- W2774505979 hasRelatedWork W2776031263 @default.
- W2774505979 hasRelatedWork W2796314825 @default.
- W2774505979 hasRelatedWork W2803781307 @default.
- W2774505979 hasRelatedWork W2883656518 @default.
- W2774505979 hasRelatedWork W2891429343 @default.
- W2774505979 hasRelatedWork W2898837130 @default.
- W2774505979 hasRelatedWork W3024418174 @default.
- W2774505979 hasRelatedWork W3029895642 @default.
- W2774505979 isParatext "false" @default.
- W2774505979 isRetracted "false" @default.
- W2774505979 magId "2774505979" @default.
- W2774505979 workType "dissertation" @default.