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- W2774509183 abstract "Abstract Core-shell novel nanocarriers were synthesized using copper oxide nanoparticle as a core and hyperbranched polyglycerol (HPG) as the shell. The shell with hydrophilic properties is solubilized and dispersed on copper oxide nanoparticles. The chemical precipitation and ring opening polymerization methods were used for the synthesis of nanoparticles. Transmission electron microscopy (TEM) and atomic force microscopy (AFM) showed the size of copper oxide NPs to be 8 nm and hyperbranched polyglycerol coated copper oxide nanoparticle to be 70 nm. X-ray diffraction (XRD) showed the purity and FT-IR determines the entire coating of copper oxide nanoparticles. Tetracycline as a soluble drug was loaded to this nano-metal polymer with the efficiency of 92% encapsulation and more than 35% of the drug released through dialysis during five days. This slow and gradual released of antibiotic can propose a promising alternative as an antibiotic carrier for chronic infection. The MTT assay showed that this nano metal branched polymer loaded with tetracycline was not cytotoxic to L929 and MCF7 cell lines." @default.
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- W2774509183 date "2018-01-01" @default.
- W2774509183 modified "2023-09-27" @default.
- W2774509183 title "Hyperbranched polyglycerol coated on copper oxide nanoparticles as a novel core-shell nano-carrier hydrophilic drug delivery model" @default.
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- W2774509183 doi "https://doi.org/10.1016/j.molliq.2017.12.031" @default.
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