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- W2774574764 endingPage "50" @default.
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- W2774574764 abstract "The positioning and movement of the nucleus has recently emerged as an important aspect of cell migration. Understanding of nuclear positioning and movement has reached an apogee in studies of fibroblast migration. Specific nuclear positioning and movements have been described in the polarization of fibroblast for cell migration and in active migration in 2D and 3D environments. Here, we review recent studies that have uncovered novel molecular mechanisms that contribute to these events in fibroblasts. Many of these involve a connection between the nucleus and the cytoskeleton through the LINC complex composed of outer nuclear membrane nesprins and inner nuclear membrane SUN proteins. We consider evidence that appropriate nuclear positioning contributes to efficient fibroblast polarization and migration and the possible mechanism through which the nucleus affects cell migration." @default.
- W2774574764 created "2017-12-22" @default.
- W2774574764 creator A5054671886 @default.
- W2774574764 creator A5054847913 @default.
- W2774574764 creator A5080158181 @default.
- W2774574764 date "2018-10-01" @default.
- W2774574764 modified "2023-10-16" @default.
- W2774574764 title "Nuclear positioning in migrating fibroblasts" @default.
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- W2774574764 doi "https://doi.org/10.1016/j.semcdb.2017.11.006" @default.
- W2774574764 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5995615" @default.
- W2774574764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29241691" @default.
- W2774574764 hasPublicationYear "2018" @default.