Matches in SemOpenAlex for { <https://semopenalex.org/work/W2774678219> ?p ?o ?g. }
- W2774678219 abstract "Neurodevelopmental disorders such as autism spectrum disorders and schizophrenia have an expansive array of reported genetic and environmental contributing factors. However, none of these factors alone can account for a substantial proportion of cases of either disorder. Instead, many gene‐by‐environment interactions are responsible for neurodevelopmental disturbances that lead to these disorders. The current experiment used heterozygous knock‐out mice to examine a potential interaction between 2 factors commonly linked to neurodevelopmental disorders and cognitive deficit: imbalanced excitatory/inhibitory signaling in the cortex and prenatal stress (PNS) exposure. Both of these factors have been linked to disrupt GABAergic signaling in the prefrontal cortex (PFC), a common feature of neurodevelopmental disorders. The neuronal PAS domain protein 4 (Npas4) gene is instrumental in regulation of the excitatory/inhibitory balance in the cortex and hippocampus in response to activation. Npas4 heterozygous and wild‐type male and female mice were exposed to either PNS or standard gestation, then evaluated during adulthood in social and anxiety behavioral measures. The combination of PNS and Npas4 deficiency in male mice impaired social recognition. This behavioral deficit was associated with decreased parvalbumin and cFos protein expression in the infralimbic region of the PFC following social stimulation in Npas4 heterozygous males. In contrast, females displayed fewer behavioral effects and molecular changes in PFC in response to PNS and decreased Npas4." @default.
- W2774678219 created "2017-12-22" @default.
- W2774678219 creator A5033977848 @default.
- W2774678219 creator A5067830455 @default.
- W2774678219 date "2018-01-01" @default.
- W2774678219 modified "2023-10-02" @default.
- W2774678219 title "Npas4 deficiency and prenatal stress interact to affect social recognition in mice" @default.
- W2774678219 cites W1480753101 @default.
- W2774678219 cites W1541267199 @default.
- W2774678219 cites W154154598 @default.
- W2774678219 cites W1973518997 @default.
- W2774678219 cites W1980815130 @default.
- W2774678219 cites W1983757175 @default.
- W2774678219 cites W1985328167 @default.
- W2774678219 cites W1987375729 @default.
- W2774678219 cites W1989597801 @default.
- W2774678219 cites W1989679792 @default.
- W2774678219 cites W1993440020 @default.
- W2774678219 cites W1994352959 @default.
- W2774678219 cites W1997075660 @default.
- W2774678219 cites W2001309356 @default.
- W2774678219 cites W2004546914 @default.
- W2774678219 cites W2017328350 @default.
- W2774678219 cites W2019885827 @default.
- W2774678219 cites W2021566700 @default.
- W2774678219 cites W2025653580 @default.
- W2774678219 cites W2028418809 @default.
- W2774678219 cites W2033776469 @default.
- W2774678219 cites W2035027696 @default.
- W2774678219 cites W2036442917 @default.
- W2774678219 cites W2037553020 @default.
- W2774678219 cites W2044271964 @default.
- W2774678219 cites W2047021875 @default.
- W2774678219 cites W2054438458 @default.
- W2774678219 cites W2068121981 @default.
- W2774678219 cites W2069985888 @default.
- W2774678219 cites W2071797996 @default.
- W2774678219 cites W2072652550 @default.
- W2774678219 cites W2074061123 @default.
- W2774678219 cites W2076507942 @default.
- W2774678219 cites W2077473360 @default.
- W2774678219 cites W2077777662 @default.
- W2774678219 cites W2079540311 @default.
- W2774678219 cites W2081263504 @default.
- W2774678219 cites W2081872173 @default.
- W2774678219 cites W2082023836 @default.
- W2774678219 cites W2087665232 @default.
- W2774678219 cites W2093012530 @default.
- W2774678219 cites W2095893084 @default.
- W2774678219 cites W2096123613 @default.
- W2774678219 cites W2098277878 @default.
- W2774678219 cites W2102092558 @default.
- W2774678219 cites W2103592460 @default.
- W2774678219 cites W2107408814 @default.
- W2774678219 cites W2109891624 @default.
- W2774678219 cites W2112851246 @default.
- W2774678219 cites W2115624750 @default.
- W2774678219 cites W2116297982 @default.
- W2774678219 cites W2121134774 @default.
- W2774678219 cites W2137036270 @default.
- W2774678219 cites W2139620666 @default.
- W2774678219 cites W2142525943 @default.
- W2774678219 cites W2143837759 @default.
- W2774678219 cites W2164671673 @default.
- W2774678219 cites W2165902261 @default.
- W2774678219 cites W2168687126 @default.
- W2774678219 cites W2170409639 @default.
- W2774678219 cites W2184917663 @default.
- W2774678219 cites W2197831217 @default.
- W2774678219 cites W2205794177 @default.
- W2774678219 cites W2271773352 @default.
- W2774678219 cites W2294066296 @default.
- W2774678219 cites W2298086467 @default.
- W2774678219 cites W2325442213 @default.
- W2774678219 cites W2490214293 @default.
- W2774678219 cites W2498283353 @default.
- W2774678219 cites W2563026252 @default.
- W2774678219 cites W259253011 @default.
- W2774678219 cites W2745966167 @default.
- W2774678219 cites W2791321831 @default.
- W2774678219 doi "https://doi.org/10.1111/gbb.12448" @default.
- W2774678219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29227584" @default.
- W2774678219 hasPublicationYear "2018" @default.
- W2774678219 type Work @default.
- W2774678219 sameAs 2774678219 @default.
- W2774678219 citedByCount "18" @default.
- W2774678219 countsByYear W27746782192018 @default.
- W2774678219 countsByYear W27746782192019 @default.
- W2774678219 countsByYear W27746782192020 @default.
- W2774678219 countsByYear W27746782192021 @default.
- W2774678219 countsByYear W27746782192022 @default.
- W2774678219 countsByYear W27746782192023 @default.
- W2774678219 crossrefType "journal-article" @default.
- W2774678219 hasAuthorship W2774678219A5033977848 @default.
- W2774678219 hasAuthorship W2774678219A5067830455 @default.
- W2774678219 hasBestOaLocation W27746782191 @default.
- W2774678219 hasConcept C118552586 @default.
- W2774678219 hasConcept C138496976 @default.
- W2774678219 hasConcept C141421786 @default.
- W2774678219 hasConcept C141547260 @default.