Matches in SemOpenAlex for { <https://semopenalex.org/work/W2774709248> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2774709248 abstract "Truncated hemoglobins (trHbs) host the heme in a ‘two-over-two’ a-helical sandwich which results from extensive editing of the classical ‘three-over-three’ globin fold. The three-dimensional structure of trHbs is based on four main u-helices, arranged in a sort of a-helical bundle composed of two antiparallel helix pairs (B/E and G/H). Most notably, trHbs deviate from the conventional globin fold in that they display an extended loop substituting for the heme proximal F-helix observed in globins. Moreover, since efficient adaptation of a 110-130 amino acid trHb chain to host the porphyrin ring firstly requires specific chain flexibility, trHbs contain three invariant Gly-based motifs. Inspection of the trHb three-dimensional trHb structures shows that an apparent protein cavity or tunnel would connect the protein surface to an inner region very close to the heme distal site. Such a structural feature, never observed before in (non) vertebrate globins, may have substantial implications for ligand diffusion and binding properties in" @default.
- W2774709248 created "2017-12-22" @default.
- W2774709248 creator A5032684463 @default.
- W2774709248 creator A5033992205 @default.
- W2774709248 creator A5057928425 @default.
- W2774709248 creator A5066081837 @default.
- W2774709248 date "2001-01-01" @default.
- W2774709248 modified "2023-09-26" @default.
- W2774709248 title "New structures Truncated hemoglobins: trimming the classical 'three-over-three' globin fold to a minimal size" @default.
- W2774709248 cites W1565582771 @default.
- W2774709248 cites W1579300096 @default.
- W2774709248 cites W160419203 @default.
- W2774709248 cites W1965266053 @default.
- W2774709248 cites W2001029839 @default.
- W2774709248 cites W2028231353 @default.
- W2774709248 cites W2062256518 @default.
- W2774709248 cites W2077428907 @default.
- W2774709248 cites W2077547350 @default.
- W2774709248 cites W2089578218 @default.
- W2774709248 cites W2090847189 @default.
- W2774709248 cites W2114334714 @default.
- W2774709248 cites W2156341767 @default.
- W2774709248 cites W2164528074 @default.
- W2774709248 cites W2295608528 @default.
- W2774709248 hasPublicationYear "2001" @default.
- W2774709248 type Work @default.
- W2774709248 sameAs 2774709248 @default.
- W2774709248 citedByCount "0" @default.
- W2774709248 crossrefType "journal-article" @default.
- W2774709248 hasAuthorship W2774709248A5032684463 @default.
- W2774709248 hasAuthorship W2774709248A5033992205 @default.
- W2774709248 hasAuthorship W2774709248A5057928425 @default.
- W2774709248 hasAuthorship W2774709248A5066081837 @default.
- W2774709248 hasConcept C115260700 @default.
- W2774709248 hasConcept C121332964 @default.
- W2774709248 hasConcept C125996951 @default.
- W2774709248 hasConcept C142089489 @default.
- W2774709248 hasConcept C185592680 @default.
- W2774709248 hasConcept C199360897 @default.
- W2774709248 hasConcept C2778917026 @default.
- W2774709248 hasConcept C41008148 @default.
- W2774709248 hasConcept C53942344 @default.
- W2774709248 hasConcept C55493867 @default.
- W2774709248 hasConcept C62520636 @default.
- W2774709248 hasConcept C71240020 @default.
- W2774709248 hasConcept C8010536 @default.
- W2774709248 hasConceptScore W2774709248C115260700 @default.
- W2774709248 hasConceptScore W2774709248C121332964 @default.
- W2774709248 hasConceptScore W2774709248C125996951 @default.
- W2774709248 hasConceptScore W2774709248C142089489 @default.
- W2774709248 hasConceptScore W2774709248C185592680 @default.
- W2774709248 hasConceptScore W2774709248C199360897 @default.
- W2774709248 hasConceptScore W2774709248C2778917026 @default.
- W2774709248 hasConceptScore W2774709248C41008148 @default.
- W2774709248 hasConceptScore W2774709248C53942344 @default.
- W2774709248 hasConceptScore W2774709248C55493867 @default.
- W2774709248 hasConceptScore W2774709248C62520636 @default.
- W2774709248 hasConceptScore W2774709248C71240020 @default.
- W2774709248 hasConceptScore W2774709248C8010536 @default.
- W2774709248 hasLocation W27747092481 @default.
- W2774709248 hasOpenAccess W2774709248 @default.
- W2774709248 hasPrimaryLocation W27747092481 @default.
- W2774709248 hasRelatedWork W1971950655 @default.
- W2774709248 hasRelatedWork W1975934117 @default.
- W2774709248 hasRelatedWork W1982581985 @default.
- W2774709248 hasRelatedWork W1985645716 @default.
- W2774709248 hasRelatedWork W199271278 @default.
- W2774709248 hasRelatedWork W2004524070 @default.
- W2774709248 hasRelatedWork W2015976014 @default.
- W2774709248 hasRelatedWork W2017403873 @default.
- W2774709248 hasRelatedWork W2019986638 @default.
- W2774709248 hasRelatedWork W2020017486 @default.
- W2774709248 hasRelatedWork W2039210384 @default.
- W2774709248 hasRelatedWork W2082928276 @default.
- W2774709248 hasRelatedWork W2125577838 @default.
- W2774709248 hasRelatedWork W2139012503 @default.
- W2774709248 hasRelatedWork W2163552994 @default.
- W2774709248 hasRelatedWork W2164192718 @default.
- W2774709248 hasRelatedWork W3202334776 @default.
- W2774709248 hasRelatedWork W2183932435 @default.
- W2774709248 hasRelatedWork W2553988403 @default.
- W2774709248 hasRelatedWork W2740620087 @default.
- W2774709248 isParatext "false" @default.
- W2774709248 isRetracted "false" @default.
- W2774709248 magId "2774709248" @default.
- W2774709248 workType "article" @default.