FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2774711313> ?p ?o ?g. }

• W2774711313 endingPage "L605" @default.
• W2774711313 startingPage "L593" @default.
• W2774711313 abstract "Pulmonary hypertension (PH) is a lethal condition, and current vasodilator therapy has limited effect. Antiproliferative strategies targeting platelet-derived growth factor (PDGF) receptors, such as imatinib, have generated promising results in animal studies. Imatinib is, however, a nonspecific tyrosine kinase inhibitor and has in clinical studies caused unacceptable adverse events. Further studies are needed on the role of PDGF signaling in PH. Here, mice expressing a variant of PDGF-B with no retention motif ( Pdgfb ret/ret ), resulting in defective binding to extracellular matrix, were studied. Following 4 wk of hypoxia, right ventricular systolic pressure, right ventricular hypertrophy, and vascular remodeling were examined. Pdgfb ret/ret mice did not develop PH, as assessed by hemodynamic parameters. Hypoxia did, however, induce vascular remodeling in Pdgfb ret/ret mice; but unlike the situation in controls where the remodeling led to an increased concentric muscularization of arteries, the vascular remodeling in Pdgfb ret/ret mice was characterized by a diffuse muscularization, in which cells expressing smooth muscle cell markers were found in the interalveolar septa detached from the normally muscularized intra-acinar vessels. Additionally, fewer NG2-positive perivascular cells were found in Pdgfb ret/ret lungs, and mRNA analyses showed significantly increased levels of Il6 following hypoxia, a known promigratory factor for pericytes. No differences in proliferation were detected at 4 wk. This study emphasizes the importance of extracellular matrix-growth factor interactions and adds to previous knowledge of PDGF-B in PH pathobiology. In summary, Pdgfb ret/ret mice have unaltered hemodynamic parameters following chronic hypoxia, possibly secondary to a disorganized vascular muscularization." @default.
• W2774711313 created "2017-12-22" @default.
• W2774711313 creator A5011586012 @default.
• W2774711313 creator A5019555799 @default.
• W2774711313 creator A5022019973 @default.
• W2774711313 creator A5030603155 @default.
• W2774711313 creator A5031968553 @default.
• W2774711313 creator A5035408607 @default.
• W2774711313 creator A5040743859 @default.
• W2774711313 creator A5051005847 @default.
• W2774711313 creator A5078288152 @default.
• W2774711313 date "2018-04-01" @default.
• W2774711313 modified "2023-10-12" @default.
• W2774711313 title "Extracellular retention of PDGF-B directs vascular remodeling in mouse hypoxia-induced pulmonary hypertension" @default.
• W2774711313 cites W1544070068 @default.
• W2774711313 cites W1633511411 @default.
• W2774711313 cites W1825951622 @default.
• W2774711313 cites W1917656545 @default.
• W2774711313 cites W1973418567 @default.
• W2774711313 cites W1975693842 @default.
• W2774711313 cites W1979770196 @default.
• W2774711313 cites W1981519579 @default.
• W2774711313 cites W1992425534 @default.
• W2774711313 cites W1998990808 @default.
• W2774711313 cites W2011477996 @default.
• W2774711313 cites W2016040720 @default.
• W2774711313 cites W2017999418 @default.
• W2774711313 cites W2026368238 @default.
• W2774711313 cites W2035317322 @default.
• W2774711313 cites W2068251212 @default.
• W2774711313 cites W2070507117 @default.
• W2774711313 cites W2080448840 @default.
• W2774711313 cites W2083991453 @default.
• W2774711313 cites W2085081729 @default.
• W2774711313 cites W2087363756 @default.
• W2774711313 cites W2094891357 @default.
• W2774711313 cites W2102920593 @default.
• W2774711313 cites W2110121929 @default.
• W2774711313 cites W2114137950 @default.
• W2774711313 cites W2114834794 @default.
• W2774711313 cites W2120608237 @default.
• W2774711313 cites W2121822802 @default.
• W2774711313 cites W2130094155 @default.
• W2774711313 cites W2147944062 @default.
• W2774711313 cites W2150029109 @default.
• W2774711313 cites W2154087679 @default.
• W2774711313 cites W2155214429 @default.
• W2774711313 cites W2165441808 @default.
• W2774711313 cites W2165968465 @default.
• W2774711313 cites W2169199162 @default.
• W2774711313 cites W2170202796 @default.
• W2774711313 cites W2170346765 @default.
• W2774711313 cites W2170779936 @default.
• W2774711313 cites W2180845934 @default.
• W2774711313 cites W2238713044 @default.
• W2774711313 cites W2267472969 @default.
• W2774711313 cites W2272122732 @default.
• W2774711313 cites W2297680570 @default.
• W2774711313 cites W2323585944 @default.
• W2774711313 cites W2328358832 @default.
• W2774711313 cites W2330445944 @default.
• W2774711313 cites W2399042156 @default.
• W2774711313 cites W2416805631 @default.
• W2774711313 cites W2496712281 @default.
• W2774711313 cites W4241408331 @default.
• W2774711313 doi "https://doi.org/10.1152/ajplung.00054.2017" @default.
• W2774711313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29212800" @default.
• W2774711313 hasPublicationYear "2018" @default.
• W2774711313 type Work @default.
• W2774711313 sameAs 2774711313 @default.
• W2774711313 citedByCount "5" @default.
• W2774711313 countsByYear W27747113132018 @default.
• W2774711313 countsByYear W27747113132019 @default.
• W2774711313 countsByYear W27747113132022 @default.
• W2774711313 countsByYear W27747113132023 @default.
• W2774711313 crossrefType "journal-article" @default.
• W2774711313 hasAuthorship W2774711313A5011586012 @default.
• W2774711313 hasAuthorship W2774711313A5019555799 @default.
• W2774711313 hasAuthorship W2774711313A5022019973 @default.
• W2774711313 hasAuthorship W2774711313A5030603155 @default.
• W2774711313 hasAuthorship W2774711313A5031968553 @default.
• W2774711313 hasAuthorship W2774711313A5035408607 @default.
• W2774711313 hasAuthorship W2774711313A5040743859 @default.
• W2774711313 hasAuthorship W2774711313A5051005847 @default.
• W2774711313 hasAuthorship W2774711313A5078288152 @default.
• W2774711313 hasBestOaLocation W27747113131 @default.
• W2774711313 hasConcept C126322002 @default.
• W2774711313 hasConcept C134018914 @default.
• W2774711313 hasConcept C167414201 @default.
• W2774711313 hasConcept C170493617 @default.
• W2774711313 hasConcept C178790620 @default.
• W2774711313 hasConcept C180361614 @default.
• W2774711313 hasConcept C185592680 @default.
• W2774711313 hasConcept C189165786 @default.
• W2774711313 hasConcept C2775960820 @default.
• W2774711313 hasConcept C2780545995 @default.
• W2774711313 hasConcept C2780930700 @default.
• W2774711313 hasConcept C2781294074 @default.

• next