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• W2774733090 abstract "Several modifications in CA-4 were reported in literature for the development of various tubulin inhibitors. In our study, twenty-two newly synthesized heterocyclic derivatives of Combretastatin A-4 (CA-4) have been tested for their cytotoxic effect on four different types of cells with malignant behavior using CA-4 as a positive control. Compounds 5b, 15 and 16 showed the foremost potent antiproliferative activities as compared to CA-4 with IC50 starting from 6.9 to 13.7 μM. Molecular docking was performed with the crystal structure of tubulin employing a potent tubulin inhibitor CA-4 as a parent molecule. Molecular study advised that 5b, 15, 16 and 17 are promising tubulin inhibitors." @default.
• W2774733090 created "2017-12-22" @default.
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• W2774733090 date "2017-01-01" @default.
• W2774733090 modified "2023-09-26" @default.
• W2774733090 title "Molecular Modeling and Synthesis of New Heterocyclic Compounds Containing Pyrazole as Anticancer Drugs" @default.
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• W2774733090 doi "https://doi.org/10.4236/ijoc.2017.74030" @default.
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