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- W2774741852 abstract "Caffeine is used for the treatment for apnoea of prematurity in patients with bronchopulmonary dysplasia (BPD). Oxygen supplementation is employed to manage BPD, but is deleterious to lung development, where patients exhibit lungs with fewer alveoli and increased alveolar septal wall thickness. It is not known whether caffeine impacts lung development per se. Therefore, the impact of caffeine (25 mg/kg/day, intraperitoneal) administration on the structural development of the lung was assessed in a hyperoxia-based mouse model of BPD, together with the effects of caffeine on transforming growth factor (TGF)-β signaling, a key modulator of lung development. Caffeine administration to newborn mouse pups prevented reductions in body mass provoked by hyperoxia exposure, and normalized Smad2 phosphorylation levels (assessed by immunoblot). However, caffeine administration had no demonstrable effect on lung structural development in experimental BPD, as assessed by stereology. Interesting, caffeine administration had parallel effects on TGF-β receptor expression in primary lung fibroblasts and epithelial cells, where expression of all three TGF-β receptors, Tgfbr1 , Tgfbr2 , and Tgfbr3 was decreased, by 25%, 32%, and 58%, respectively, at the mRNA level (assessed by real-time RT-PCR); which was not observed in A549 cells, where Smad7 mRNA levels were reduced by 25%. These data highlight important differences between primary lung epithelial cells and the widely-used A549 immortalized lung epithelial cell-line. In sum, these data indicate that while caffeine may be useful for the management of apnoea of prematurity, caffeine does not impact normal or aberrant lung development, despite effects on TGF-β signalling." @default.
- W2774741852 created "2017-12-22" @default.
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- W2774741852 date "2017-09-01" @default.
- W2774741852 modified "2023-09-27" @default.
- W2774741852 title "The impact of caffeine on TGF-β signaling and brochopulmonary dysplasia" @default.
- W2774741852 doi "https://doi.org/10.1183/1393003.congress-2017.pa2090" @default.
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