Matches in SemOpenAlex for { <https://semopenalex.org/work/W2774749130> ?p ?o ?g. }
- W2774749130 endingPage "210" @default.
- W2774749130 startingPage "201" @default.
- W2774749130 abstract "Photodynamic therapy is an advanced method of treating cancer and various benign diseases, including infections. It uses light‐activated molecules [photosensitizers (PSs)] to generate reactive oxygen species ( ROS ) when irradiated with light of a specific wavelength. This study examined the photophysical and photosensitizing activity of the PS chlorin e6 incorporated in a delivery system based on plant phospholipids. This new nanoform of chlorin e6 comprised particles with a diameter of 18.4 ± 2.5 nm and zeta potential of −34.6 ± 3.0 mV. Incorporation of chlorin e6 in phospholipid nanoparticles was observed to cause a bathochromic shift of Q‐band absorption maximum by 14 nm without an absorption change in the range of the Soret band. Fluorescence intensity of chlorin e6 embedded in the phospholipid nanoparticles increased 1.7‐fold. Chlorin e6 in phospholipid nanoparticles, when irradiated, was able to generate ROS as shown by oxidation of polyunsaturated fatty acids of the phospholipid matrix of the delivery system and reduced l ‐glutathione. In vivo it was demonstrated that the new nanoform of chlorin e6 provides more accumulation of PSs in tumor tissue than its free form. Moreover, its accumulation in the skin was lower and its elimination from the skin almost five times faster than when administered in free form. The observed differences of this new nanoform of chlorin e6 should lead to enhancement of antitumor efficacy and a decrease in phototoxicity." @default.
- W2774749130 created "2017-12-22" @default.
- W2774749130 creator A5022194120 @default.
- W2774749130 creator A5056913849 @default.
- W2774749130 creator A5081709164 @default.
- W2774749130 creator A5090493036 @default.
- W2774749130 date "2018-01-02" @default.
- W2774749130 modified "2023-10-14" @default.
- W2774749130 title "Comparison of a new nanoform of the photosensitizer chlorin e6, based on plant phospholipids, with its free form" @default.
- W2774749130 cites W1967637067 @default.
- W2774749130 cites W1969371399 @default.
- W2774749130 cites W1971138677 @default.
- W2774749130 cites W1973505459 @default.
- W2774749130 cites W1981657842 @default.
- W2774749130 cites W1982224969 @default.
- W2774749130 cites W1993301566 @default.
- W2774749130 cites W1998258483 @default.
- W2774749130 cites W2012081876 @default.
- W2774749130 cites W2017603533 @default.
- W2774749130 cites W2021577405 @default.
- W2774749130 cites W2038023276 @default.
- W2774749130 cites W2042706019 @default.
- W2774749130 cites W2060011496 @default.
- W2774749130 cites W2061650771 @default.
- W2774749130 cites W2062197253 @default.
- W2774749130 cites W2064296350 @default.
- W2774749130 cites W2070827800 @default.
- W2774749130 cites W2078856262 @default.
- W2774749130 cites W2085039948 @default.
- W2774749130 cites W2087202509 @default.
- W2774749130 cites W2089911291 @default.
- W2774749130 cites W2110722654 @default.
- W2774749130 cites W2133720275 @default.
- W2774749130 cites W2134213080 @default.
- W2774749130 cites W2143405687 @default.
- W2774749130 cites W2147147011 @default.
- W2774749130 cites W2164526630 @default.
- W2774749130 cites W2285624195 @default.
- W2774749130 cites W2293461885 @default.
- W2774749130 cites W2310705979 @default.
- W2774749130 cites W2317146433 @default.
- W2774749130 cites W2337485356 @default.
- W2774749130 cites W2478577505 @default.
- W2774749130 cites W2549103576 @default.
- W2774749130 cites W2571146127 @default.
- W2774749130 cites W2579952824 @default.
- W2774749130 cites W2582916840 @default.
- W2774749130 cites W2590947287 @default.
- W2774749130 cites W2595421589 @default.
- W2774749130 cites W2602458018 @default.
- W2774749130 cites W2606015276 @default.
- W2774749130 cites W3024088771 @default.
- W2774749130 cites W4248078302 @default.
- W2774749130 doi "https://doi.org/10.1002/2211-5463.12359" @default.
- W2774749130 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5794465" @default.
- W2774749130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29435410" @default.
- W2774749130 hasPublicationYear "2018" @default.
- W2774749130 type Work @default.
- W2774749130 sameAs 2774749130 @default.
- W2774749130 citedByCount "25" @default.
- W2774749130 countsByYear W27747491302018 @default.
- W2774749130 countsByYear W27747491302019 @default.
- W2774749130 countsByYear W27747491302020 @default.
- W2774749130 countsByYear W27747491302021 @default.
- W2774749130 countsByYear W27747491302022 @default.
- W2774749130 crossrefType "journal-article" @default.
- W2774749130 hasAuthorship W2774749130A5022194120 @default.
- W2774749130 hasAuthorship W2774749130A5056913849 @default.
- W2774749130 hasAuthorship W2774749130A5081709164 @default.
- W2774749130 hasAuthorship W2774749130A5090493036 @default.
- W2774749130 hasBestOaLocation W27747491301 @default.
- W2774749130 hasConcept C12554922 @default.
- W2774749130 hasConcept C178790620 @default.
- W2774749130 hasConcept C185154212 @default.
- W2774749130 hasConcept C185592680 @default.
- W2774749130 hasConcept C202751555 @default.
- W2774749130 hasConcept C20639190 @default.
- W2774749130 hasConcept C2778093064 @default.
- W2774749130 hasConcept C2778178086 @default.
- W2774749130 hasConcept C2778918659 @default.
- W2774749130 hasConcept C2779669040 @default.
- W2774749130 hasConcept C2781323092 @default.
- W2774749130 hasConcept C2781469039 @default.
- W2774749130 hasConcept C41625074 @default.
- W2774749130 hasConcept C523546767 @default.
- W2774749130 hasConcept C54355233 @default.
- W2774749130 hasConcept C55493867 @default.
- W2774749130 hasConcept C75473681 @default.
- W2774749130 hasConcept C86803240 @default.
- W2774749130 hasConceptScore W2774749130C12554922 @default.
- W2774749130 hasConceptScore W2774749130C178790620 @default.
- W2774749130 hasConceptScore W2774749130C185154212 @default.
- W2774749130 hasConceptScore W2774749130C185592680 @default.
- W2774749130 hasConceptScore W2774749130C202751555 @default.
- W2774749130 hasConceptScore W2774749130C20639190 @default.
- W2774749130 hasConceptScore W2774749130C2778093064 @default.
- W2774749130 hasConceptScore W2774749130C2778178086 @default.
- W2774749130 hasConceptScore W2774749130C2778918659 @default.