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- W2774764734 abstract "Introduction: An enhancement in knowledge of asthma phenotypes allows an optimal treatment choice and improves disease control. Objective: 1) To describe the phenotypes of patients (pts) with severe asthma (SA) full controlled after 1 year on omalizumab (OMA) 2) Reduction in: symptoms and non-severe asthma exacerbations (NSAE), work absenteeism and medication intake 3) lung function improvement. Methods: Spanish observational, retrospective, multicentric study in pts≥18 years and persistent SA who achieved disease control after 1 year on OMA. Phenotypes classification: early onset allergic asthma (EOA), SA with frequent exacerbations (SAFE), asthma with persistent airway obstruction (APAO), steroid-dependent SA (SDA), hypereosinophilic SA and SA in obese women. Measured variables were: NSAE and symptoms reduction, oral (OC) and inhaled corticosteroid (IC) intake, rescue medication, work absenteeism and lung function (FEV1). Results: 345 pts (66.7% women, mean age 48.6 years) were included. Main phenotypes: SAFE (29.9%), EOA (23.7%), SDA (18.0%), hypereosinophilic SA (13.6%), APAO (9.3%) and SA in obese women (5.5%). After 1 year with OMA, 55.4% had no symptoms, 36.4% reduced OC and 49.9% IC, 55.7% didn’t need rescue medication. Mean change (95%CI) in FEV1(%) was +14.7% (13.2-16.3). NSAE and work absenteeism days decreased (mean [SD] 9.8 [29.3] vs 1.3 [2.2] exacerbations; 12.4 [39.2] vs 0.6 [2.3] days). Conclusions: EOA and SAFE were most common phenotypes in OMA-treated SA pts who achieve disease full control. After 1 year with OMA: lung function improved and there was a reduction of maintenance/rescue medication use, unscheduled visits and work absenteeism." @default.
- W2774764734 created "2017-12-22" @default.
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- W2774764734 date "2017-09-01" @default.
- W2774764734 modified "2023-10-17" @default.
- W2774764734 title "Phenotypes related with clinical improvement of omalizumab-treated patients in routine clinical practice. FENOMA Study" @default.
- W2774764734 doi "https://doi.org/10.1183/1393003.congress-2017.pa3573" @default.
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