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- W2774813144 abstract "Test the putative contribution of 17-β-estradiol in the development of spreading depression (SD) events and head pain in awake, non-restrained rats.Female, Sprague-Dawley rats were intact or underwent ovariectomy followed one week later by surgery to place electrodes onto the dura to detect epidural electroencephalographic activity (dEEG). dEEG activity was recorded two days later for 12 hours after systemic administration of 17-β-estradiol (180 μg/kg, i.p.). A separate set of rats were observed for changes in exploratory, ambulatory, fine, and rearing behaviors; periorbital allodynia was also assessed.A bolus of 17-β-estradiol significantly elevated serum estrogen levels, increased SD episodes over a 12-hour recording period and decreased rearing behaviors in ovariectomized rats. Pre-administration of ICI 182,780, an estrogen receptor antagonist, blocked 17-β-estradiol-evoked SD events and pain behaviors; similar results were observed when the antimigraine therapeutic sumatriptan was used.These data indicate that an estrogen receptor-mediated mechanism contributes to SD events in ovariectomized rats and pain behaviors in both ovariectomized -and intact- rats. This suggests that estrogen plays a different role in each phenomenon of migraine where intense fluctuations in concentration may influence SD susceptibility. This is the first study to relate estrogen peaks to SD development and pain behaviors in awake, freely moving female rats, establishing a framework for future preclinical migraine studies." @default.
- W2774813144 created "2017-12-22" @default.
- W2774813144 creator A5017503792 @default.
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- W2774813144 creator A5087404698 @default.
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- W2774813144 creator A5090974511 @default.
- W2774813144 date "2017-12-09" @default.
- W2774813144 modified "2023-10-12" @default.
- W2774813144 title "17-β-Estradiol induces spreading depression and pain behavior in alert female rats" @default.
- W2774813144 cites W126246644 @default.
- W2774813144 cites W1572505992 @default.
- W2774813144 cites W1615663866 @default.
- W2774813144 cites W172982314 @default.
- W2774813144 cites W1828894964 @default.
- W2774813144 cites W1936894535 @default.
- W2774813144 cites W1963591991 @default.
- W2774813144 cites W1966206022 @default.
- W2774813144 cites W1971487571 @default.
- W2774813144 cites W1971920666 @default.
- W2774813144 cites W1972794886 @default.
- W2774813144 cites W1976735920 @default.
- W2774813144 cites W1982002301 @default.
- W2774813144 cites W1983645205 @default.
- W2774813144 cites W1986367140 @default.
- W2774813144 cites W1987957917 @default.
- W2774813144 cites W1995010151 @default.
- W2774813144 cites W2000233515 @default.
- W2774813144 cites W2001538229 @default.
- W2774813144 cites W2002101128 @default.
- W2774813144 cites W2002903785 @default.
- W2774813144 cites W2003509571 @default.
- W2774813144 cites W2005702212 @default.
- W2774813144 cites W2005766913 @default.
- W2774813144 cites W2006821434 @default.
- W2774813144 cites W2009853943 @default.
- W2774813144 cites W2012658494 @default.
- W2774813144 cites W2012782470 @default.
- W2774813144 cites W2013160796 @default.
- W2774813144 cites W2014337501 @default.
- W2774813144 cites W2015074342 @default.
- W2774813144 cites W2018694608 @default.
- W2774813144 cites W2020841505 @default.
- W2774813144 cites W2022417940 @default.
- W2774813144 cites W2023102259 @default.
- W2774813144 cites W2028210835 @default.
- W2774813144 cites W2028506346 @default.
- W2774813144 cites W2028740698 @default.
- W2774813144 cites W2029392538 @default.
- W2774813144 cites W2031425841 @default.
- W2774813144 cites W2038218097 @default.
- W2774813144 cites W2043649476 @default.
- W2774813144 cites W2047041272 @default.
- W2774813144 cites W2047345715 @default.
- W2774813144 cites W2050235583 @default.
- W2774813144 cites W2052494792 @default.
- W2774813144 cites W2054086919 @default.
- W2774813144 cites W2054292719 @default.
- W2774813144 cites W2056439165 @default.
- W2774813144 cites W2059649492 @default.
- W2774813144 cites W2059762852 @default.
- W2774813144 cites W2061310823 @default.
- W2774813144 cites W2061999237 @default.
- W2774813144 cites W2064377700 @default.
- W2774813144 cites W2064380497 @default.
- W2774813144 cites W2064845499 @default.
- W2774813144 cites W2065605263 @default.
- W2774813144 cites W2066875663 @default.
- W2774813144 cites W2070528905 @default.
- W2774813144 cites W2071441011 @default.
- W2774813144 cites W2072681068 @default.
- W2774813144 cites W2074050181 @default.
- W2774813144 cites W2076759601 @default.
- W2774813144 cites W2078794100 @default.
- W2774813144 cites W2080276852 @default.
- W2774813144 cites W2081236301 @default.
- W2774813144 cites W2083330259 @default.
- W2774813144 cites W2083727172 @default.
- W2774813144 cites W2083796319 @default.
- W2774813144 cites W2084015789 @default.
- W2774813144 cites W2086409580 @default.
- W2774813144 cites W2088424574 @default.
- W2774813144 cites W2088906203 @default.
- W2774813144 cites W2088981463 @default.
- W2774813144 cites W2092678864 @default.
- W2774813144 cites W2095582751 @default.
- W2774813144 cites W2096198144 @default.
- W2774813144 cites W2097311328 @default.
- W2774813144 cites W2104522926 @default.
- W2774813144 cites W2106164636 @default.
- W2774813144 cites W2130739181 @default.
- W2774813144 cites W2134748549 @default.
- W2774813144 cites W2134914347 @default.
- W2774813144 cites W2136164241 @default.
- W2774813144 cites W2139921115 @default.
- W2774813144 cites W2140420891 @default.