FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2774818784> ?p ?o ?g. }

• W2774818784 endingPage "391" @default.
• W2774818784 startingPage "383" @default.
• W2774818784 abstract "Recent studies suggest improved survival in patients with severe aplastic anemia receiving hematopoietic cell transplant (HCT) from unrelated donors with longer telomeres. Here, we tested whether this effect is generalizable to patients with acute leukemia. From the Center for International Blood and Marrow Transplant Research (CIBMTR®) database, we identified 1097 patients who received 8/8 HLA-matched unrelated HCT for acute myeloid leukemia (AML) or acute lymphocytic leukemia (ALL) between 2004 and 2012 with myeloablative conditioning, and had pre-HCT blood sample from the donor in CIBMTR repository. The median age at HCT for recipients was 40 years (range ≤1–68), and 32 years for donors (range = 18–61). We used qPCR for relative telomere length (RTL) measurement, and Cox proportional hazard models for statistical analyses. In a discovery cohort of 300 patients, longer donor RTL (>25th percentile) was associated with reduced risks of relapse (HR = 0.62, p = 0.05) and acute graft-versus-host disease II–IV (HR = 0.68, p = 0.05), and possibly with a higher probability of neutrophil engraftment (HR = 1.3, p = 0.06). However, these results did not replicate in two validation cohorts of 297 and 488 recipients. There was one exception; a higher probability of neutrophil engraftment was observed in one validation cohort (HR = 1.24, p = 0.05). In a combined analysis of the three cohorts, no statistically significant associations (all p > 0.1) were found between donor RTL and any outcomes." @default.
• W2774818784 created "2017-12-22" @default.
• W2774818784 creator A5001006245 @default.
• W2774818784 creator A5006363663 @default.
• W2774818784 creator A5006635511 @default.
• W2774818784 creator A5009609420 @default.
• W2774818784 creator A5027599215 @default.
• W2774818784 creator A5031390636 @default.
• W2774818784 creator A5039857143 @default.
• W2774818784 creator A5056539557 @default.
• W2774818784 creator A5057135821 @default.
• W2774818784 creator A5059316482 @default.
• W2774818784 creator A5061304526 @default.
• W2774818784 creator A5064422904 @default.
• W2774818784 creator A5064818358 @default.
• W2774818784 creator A5067533895 @default.
• W2774818784 creator A5068089636 @default.
• W2774818784 creator A5070378721 @default.
• W2774818784 creator A5073226546 @default.
• W2774818784 creator A5085142676 @default.
• W2774818784 date "2017-12-21" @default.
• W2774818784 modified "2023-10-17" @default.
• W2774818784 title "No association between donor telomere length and outcomes after allogeneic unrelated hematopoietic cell transplant in patients with acute leukemia" @default.
• W2774818784 cites W1274344746 @default.
• W2774818784 cites W1589363997 @default.
• W2774818784 cites W1971419826 @default.
• W2774818784 cites W1972644623 @default.
• W2774818784 cites W1973617793 @default.
• W2774818784 cites W1982068584 @default.
• W2774818784 cites W2008928916 @default.
• W2774818784 cites W2017218670 @default.
• W2774818784 cites W2020545711 @default.
• W2774818784 cites W2026761826 @default.
• W2774818784 cites W2033149855 @default.
• W2774818784 cites W2050302428 @default.
• W2774818784 cites W2052468427 @default.
• W2774818784 cites W2056176559 @default.
• W2774818784 cites W2070414796 @default.
• W2774818784 cites W2081316165 @default.
• W2774818784 cites W2102637503 @default.
• W2774818784 cites W2109285747 @default.
• W2774818784 cites W2114447071 @default.
• W2774818784 cites W2124142246 @default.
• W2774818784 cites W2140143467 @default.
• W2774818784 cites W2160621707 @default.
• W2774818784 cites W2336855366 @default.
• W2774818784 cites W2337759633 @default.
• W2774818784 cites W2466031142 @default.
• W2774818784 cites W2475137382 @default.
• W2774818784 cites W2498880250 @default.
• W2774818784 cites W2520431433 @default.
• W2774818784 doi "https://doi.org/10.1038/s41409-017-0029-9" @default.
• W2774818784 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5898974" @default.
• W2774818784 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29269807" @default.
• W2774818784 hasPublicationYear "2017" @default.
• W2774818784 type Work @default.
• W2774818784 sameAs 2774818784 @default.
• W2774818784 citedByCount "13" @default.
• W2774818784 countsByYear W27748187842018 @default.
• W2774818784 countsByYear W27748187842019 @default.
• W2774818784 countsByYear W27748187842020 @default.
• W2774818784 countsByYear W27748187842021 @default.
• W2774818784 countsByYear W27748187842022 @default.
• W2774818784 crossrefType "journal-article" @default.
• W2774818784 hasAuthorship W2774818784A5001006245 @default.
• W2774818784 hasAuthorship W2774818784A5006363663 @default.
• W2774818784 hasAuthorship W2774818784A5006635511 @default.
• W2774818784 hasAuthorship W2774818784A5009609420 @default.
• W2774818784 hasAuthorship W2774818784A5027599215 @default.
• W2774818784 hasAuthorship W2774818784A5031390636 @default.
• W2774818784 hasAuthorship W2774818784A5039857143 @default.
• W2774818784 hasAuthorship W2774818784A5056539557 @default.
• W2774818784 hasAuthorship W2774818784A5057135821 @default.
• W2774818784 hasAuthorship W2774818784A5059316482 @default.
• W2774818784 hasAuthorship W2774818784A5061304526 @default.
• W2774818784 hasAuthorship W2774818784A5064422904 @default.
• W2774818784 hasAuthorship W2774818784A5064818358 @default.
• W2774818784 hasAuthorship W2774818784A5067533895 @default.
• W2774818784 hasAuthorship W2774818784A5068089636 @default.
• W2774818784 hasAuthorship W2774818784A5070378721 @default.
• W2774818784 hasAuthorship W2774818784A5073226546 @default.
• W2774818784 hasAuthorship W2774818784A5085142676 @default.
• W2774818784 hasBestOaLocation W27748187841 @default.
• W2774818784 hasConcept C104317684 @default.
• W2774818784 hasConcept C126322002 @default.
• W2774818784 hasConcept C143998085 @default.
• W2774818784 hasConcept C203014093 @default.
• W2774818784 hasConcept C207103383 @default.
• W2774818784 hasConcept C2483381 @default.
• W2774818784 hasConcept C2776863199 @default.
• W2774818784 hasConcept C2777408962 @default.
• W2774818784 hasConcept C2778461978 @default.
• W2774818784 hasConcept C2780007613 @default.
• W2774818784 hasConcept C2781107101 @default.
• W2774818784 hasConcept C2781440808 @default.
• W2774818784 hasConcept C2909962599 @default.
• W2774818784 hasConcept C2911091166 @default.
• W2774818784 hasConcept C30481170 @default.

• next