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- W2774855008 abstract "Stromal interaction molecule 1 (STIM1) along with Orai1 mediates extracellular Ca2+ entry into the cytosol through a store-operated Ca2+ entry (SOCE) mechanism in various tissues including skeletal muscle. However, the role(s) of STIM2, a homolog of STIM1, in skeletal muscle has not been well addressed. The present study, first, was focused on searching for STIM2-binding proteins from among proteins mediating skeletal muscle functions. This study used a binding assay, quadrupole time-of-flight mass spectrometry, and co-immunoprecipitation assay with bona-fide STIM2- and SERCA1a-expressing rabbit skeletal muscle. The region for amino acids from 453 to 729 of STIM2 binds to sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 1a (SERCA1a). Next, oxalate-supported 45Ca2+-uptake experiments and various single-myotube Ca2+ imaging experiments using STIM2-knockdown mouse primary skeletal myotubes have suggested that STIM2 attenuates SERCA1a activity during skeletal muscle contraction, which contributes to the intracellular Ca2+ distribution between the cytosol and the SR at rest. In addition, STIM2 regulates Ca2+ movement through RyR1 during skeletal muscle contraction as well as SOCE. Therefore, via regulation of SERCA1a activity, STIM2 regulates both intracellular Ca2+ distribution and Ca2+ movement in skeletal muscle, which makes it both similar to, yet different from, STIM1." @default.
- W2774855008 created "2017-12-22" @default.
- W2774855008 creator A5011997532 @default.
- W2774855008 creator A5022974146 @default.
- W2774855008 creator A5026360578 @default.
- W2774855008 creator A5032467990 @default.
- W2774855008 creator A5045470478 @default.
- W2774855008 creator A5063732125 @default.
- W2774855008 creator A5085802899 @default.
- W2774855008 date "2017-12-20" @default.
- W2774855008 modified "2023-10-01" @default.
- W2774855008 title "STIM2 regulates both intracellular Ca2+ distribution and Ca2+ movement in skeletal myotubes" @default.
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