Matches in SemOpenAlex for { <https://semopenalex.org/work/W2774880273> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2774880273 endingPage "424" @default.
- W2774880273 startingPage "416" @default.
- W2774880273 abstract "Novel biocompatible and biodegradable pH/reduction dual-responsive oxidized alginate-doxorubicin (mPEG-OAL-DOX/Cys) prodrug nanohydrogels were designed for tumor-specific intracellular triggered release of anticancer drug DOX by conjugating DOX via acid-labile Schiff base linkage into the PEGylated oxidized alginate (mPEG-OAL) cross-linked with bioreducible disulfide bond. The effect of the complexation with cyclodextrins (α-CD and β-CD) before or after the cross-linking of the mPEG-OAL on the DOX content and controlled release performance was investigated. It was found that the cyclodextrin inclusion complex prodrug nanohydrogels mPEG(CD)-OAL-DOX/Cys, prepared by cross-linking of the mPEG-OAL after complexation with cyclodextrins, exhibited better pH/reduction dual-responsive controlled release performance than the mPEG-OAL-DOX/Cys(CD) ones prepared by cross-linking of the mPEG-OAL before complexation with cyclodextrins, owing to the supramolecular cross-linking of the adjacent pseudopolyrotaxanes. Especially for the cyclodextrin inclusion complex prodrug nanohydrogels mPEG(α-CD)-OAL-DOX/Cys, DOX was released rapidly under lower pH media mimicking the tumor microenvironment and completely released within 48 h, while the premature leakage under the simulated physiological condition was ∼40%, without burst release in both cases. The cellular toxicity and uptake results demonstrated that the mPEG(α-CD)-OAL-DOX/Cys prodrug nanohydrogels possessed similar inhibition against cancer cell growth in comparison with the free DOX and enhanced drug intracellular accumulation." @default.
- W2774880273 created "2017-12-22" @default.
- W2774880273 creator A5013663293 @default.
- W2774880273 creator A5029004987 @default.
- W2774880273 creator A5061078777 @default.
- W2774880273 creator A5075195590 @default.
- W2774880273 creator A5090193561 @default.
- W2774880273 date "2017-12-27" @default.
- W2774880273 modified "2023-10-14" @default.
- W2774880273 title "pH/Reduction Dual-Responsive Oxidized Alginate-Doxorubicin (mPEG-OAL-DOX/Cys) Prodrug Nanohydrogels: Effect of Complexation with Cyclodextrins" @default.
- W2774880273 cites W1819174152 @default.
- W2774880273 cites W1843302206 @default.
- W2774880273 cites W1971500643 @default.
- W2774880273 cites W1974089541 @default.
- W2774880273 cites W1991721070 @default.
- W2774880273 cites W2009269965 @default.
- W2774880273 cites W2038116174 @default.
- W2774880273 cites W2047866615 @default.
- W2774880273 cites W2078593168 @default.
- W2774880273 cites W2117999189 @default.
- W2774880273 cites W2128653175 @default.
- W2774880273 cites W2132551021 @default.
- W2774880273 cites W2148145619 @default.
- W2774880273 cites W2289266478 @default.
- W2774880273 cites W2306471161 @default.
- W2774880273 cites W2330297021 @default.
- W2774880273 cites W2333866981 @default.
- W2774880273 cites W2344598639 @default.
- W2774880273 cites W2413962185 @default.
- W2774880273 cites W2477717923 @default.
- W2774880273 cites W2499288178 @default.
- W2774880273 cites W2512843523 @default.
- W2774880273 cites W2517840899 @default.
- W2774880273 cites W2543322000 @default.
- W2774880273 cites W2590788402 @default.
- W2774880273 cites W2602213142 @default.
- W2774880273 cites W2610816916 @default.
- W2774880273 cites W4251829210 @default.
- W2774880273 cites W777420780 @default.
- W2774880273 doi "https://doi.org/10.1021/acs.langmuir.7b03990" @default.
- W2774880273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29237263" @default.
- W2774880273 hasPublicationYear "2017" @default.
- W2774880273 type Work @default.
- W2774880273 sameAs 2774880273 @default.
- W2774880273 citedByCount "22" @default.
- W2774880273 countsByYear W27748802732018 @default.
- W2774880273 countsByYear W27748802732019 @default.
- W2774880273 countsByYear W27748802732020 @default.
- W2774880273 countsByYear W27748802732021 @default.
- W2774880273 countsByYear W27748802732022 @default.
- W2774880273 countsByYear W27748802732023 @default.
- W2774880273 crossrefType "journal-article" @default.
- W2774880273 hasAuthorship W2774880273A5013663293 @default.
- W2774880273 hasAuthorship W2774880273A5029004987 @default.
- W2774880273 hasAuthorship W2774880273A5061078777 @default.
- W2774880273 hasAuthorship W2774880273A5075195590 @default.
- W2774880273 hasAuthorship W2774880273A5090193561 @default.
- W2774880273 hasConcept C108215921 @default.
- W2774880273 hasConcept C126322002 @default.
- W2774880273 hasConcept C185592680 @default.
- W2774880273 hasConcept C2776694085 @default.
- W2774880273 hasConcept C2779433975 @default.
- W2774880273 hasConcept C2781303535 @default.
- W2774880273 hasConcept C55493867 @default.
- W2774880273 hasConcept C71924100 @default.
- W2774880273 hasConceptScore W2774880273C108215921 @default.
- W2774880273 hasConceptScore W2774880273C126322002 @default.
- W2774880273 hasConceptScore W2774880273C185592680 @default.
- W2774880273 hasConceptScore W2774880273C2776694085 @default.
- W2774880273 hasConceptScore W2774880273C2779433975 @default.
- W2774880273 hasConceptScore W2774880273C2781303535 @default.
- W2774880273 hasConceptScore W2774880273C55493867 @default.
- W2774880273 hasConceptScore W2774880273C71924100 @default.
- W2774880273 hasIssue "1" @default.
- W2774880273 hasLocation W27748802731 @default.
- W2774880273 hasLocation W27748802732 @default.
- W2774880273 hasOpenAccess W2774880273 @default.
- W2774880273 hasPrimaryLocation W27748802731 @default.
- W2774880273 hasRelatedWork W1873645780 @default.
- W2774880273 hasRelatedWork W1943660350 @default.
- W2774880273 hasRelatedWork W1973231587 @default.
- W2774880273 hasRelatedWork W2040818997 @default.
- W2774880273 hasRelatedWork W2052029677 @default.
- W2774880273 hasRelatedWork W2086942498 @default.
- W2774880273 hasRelatedWork W2159195482 @default.
- W2774880273 hasRelatedWork W2387437904 @default.
- W2774880273 hasRelatedWork W2415165048 @default.
- W2774880273 hasRelatedWork W2759100261 @default.
- W2774880273 hasVolume "34" @default.
- W2774880273 isParatext "false" @default.
- W2774880273 isRetracted "false" @default.
- W2774880273 magId "2774880273" @default.
- W2774880273 workType "article" @default.