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- W2774883265 abstract "In Turner syndrome, the potential to form thoracic aortic aneurysms requires routine patient monitoring. However, the short stature that typically occurs complicates the assessment of severity and risk because the relationship of body size to aortic dimensions is different in Turner syndrome compared to the general population. Three allometric formula have been proposed to adjust aortic dimensions, all employing body surface area: aortic size index, Turner syndrome‐specific Z‐scores, and Z‐scores based on a general pediatric and young adult population. In order to understand the differences between these formula we evaluated the relationship between age and aortic size index and compared Turner syndrome‐specific Z‐scores and pediatric/young adult based Z‐scores in a group of girls and women with Turner syndrome. Our results suggest that the aortic size index is highly age‐dependent for those under 15 years; and that Turner‐specific Z‐scores are significantly lower than Z‐scores referenced to the general population. Higher Z‐scores derived from the general reference population could result in stigmatization, inappropriate restriction from sports, and increasing the risk of unneeded medical or operative treatments. We propose that when estimating aortic dissection risk clinicians use Turner syndrome‐specific Z‐score for those under fifteen years of age." @default.
- W2774883265 created "2017-12-22" @default.
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- W2774883265 date "2017-12-15" @default.
- W2774883265 modified "2023-10-16" @default.
- W2774883265 title "Allometric considerations when assessing aortic aneurysms in Turner syndrome: Implications for activity recommendations and medical decision‐making" @default.
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- W2774883265 doi "https://doi.org/10.1002/ajmg.a.38584" @default.
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