Matches in SemOpenAlex for { <https://semopenalex.org/work/W2774903098> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2774903098 endingPage "192" @default.
- W2774903098 startingPage "192" @default.
- W2774903098 abstract "Introduction: Regulatory T cells (Treg) have potential to regulate alloantigens and thus may counteract the development of chronic rejection (i.e. bronchiolitis obliterans syndrome, BOS) in lung transplantation. BOS may affect over 60% of lung transplant recipients within five years. Here, we analyzed Tregs in peripheral blood of 150 lung recipients prospectively during the first 3 years and correlated with the onset of BOS at two years. Materials and Methods: In this study we detected circulating Treg by flow cytrometry in consecutive routine lung transplant recipients before transplantation 3 weeks, 3, 6, 12, 18, 24 and 36 months after transplantation. Treg were defined as CD4+CD25high T cells and were further analyzed for relevant surface as well as intracellular markers such as, amongst others, CTLA4, CD127, FoxP3 and IL-2. Spirometry at 3 weeks, 3, 6, 12, 18, 24 and 36 months after transplantation as well as protocol biopsy results were analyzed. We defined two groups by the development of BOS stage 1 or higher versus BOS stage 0 at two years. Results: A total of 150 consecutive patients were included into the study. While 103 patients showed a stable clinical course after lung transplantation, 47 patients developed BOS stage 1 or higher within the first 2 years after lung transplantation. As soon as 3 weeks after lung transplantation not only a statistically significant positive correlation could be detected between the frequencies of Tregs and the absence of BOS (p<0.05), we also built a score defining a cut off value composed of IL2+/CTLA4+/CD127low and FoxP3+ Treg in peripheral blood at 3 weeks, predicting the probability of BOS development. A total percentage of 40.5 of the lung recipients were found below the cut off value, defining a BOS risk of 79.5%. Those 59.5% of the patients remaining above the cut off had a BOS risk at two years of 0%. Conclusions: Higher frequencies of Treg early after lung transplantation are associated with protection against development of BOS and they may thus have an early predictive function for the ensuing course following transplantation." @default.
- W2774903098 created "2017-12-22" @default.
- W2774903098 creator A5001013964 @default.
- W2774903098 creator A5004233423 @default.
- W2774903098 creator A5005890783 @default.
- W2774903098 creator A5019934741 @default.
- W2774903098 creator A5027209248 @default.
- W2774903098 creator A5033803866 @default.
- W2774903098 creator A5042536098 @default.
- W2774903098 creator A5043152068 @default.
- W2774903098 creator A5044317096 @default.
- W2774903098 creator A5054000405 @default.
- W2774903098 creator A5079491654 @default.
- W2774903098 creator A5084519339 @default.
- W2774903098 creator A5087432330 @default.
- W2774903098 date "2014-07-01" @default.
- W2774903098 modified "2023-10-16" @default.
- W2774903098 title "Developing a Score of Early Postoperative Regulatory T Cell Frequency to Predict Bronchiolitis Obliterans Syndrome-Free Survival at Two Years After Lung Transplantation." @default.
- W2774903098 doi "https://doi.org/10.1097/00007890-201407151-00577" @default.
- W2774903098 hasPublicationYear "2014" @default.
- W2774903098 type Work @default.
- W2774903098 sameAs 2774903098 @default.
- W2774903098 citedByCount "0" @default.
- W2774903098 crossrefType "journal-article" @default.
- W2774903098 hasAuthorship W2774903098A5001013964 @default.
- W2774903098 hasAuthorship W2774903098A5004233423 @default.
- W2774903098 hasAuthorship W2774903098A5005890783 @default.
- W2774903098 hasAuthorship W2774903098A5019934741 @default.
- W2774903098 hasAuthorship W2774903098A5027209248 @default.
- W2774903098 hasAuthorship W2774903098A5033803866 @default.
- W2774903098 hasAuthorship W2774903098A5042536098 @default.
- W2774903098 hasAuthorship W2774903098A5043152068 @default.
- W2774903098 hasAuthorship W2774903098A5044317096 @default.
- W2774903098 hasAuthorship W2774903098A5054000405 @default.
- W2774903098 hasAuthorship W2774903098A5079491654 @default.
- W2774903098 hasAuthorship W2774903098A5084519339 @default.
- W2774903098 hasAuthorship W2774903098A5087432330 @default.
- W2774903098 hasConcept C126322002 @default.
- W2774903098 hasConcept C146357865 @default.
- W2774903098 hasConcept C151730666 @default.
- W2774903098 hasConcept C203014093 @default.
- W2774903098 hasConcept C2776042228 @default.
- W2774903098 hasConcept C2776739411 @default.
- W2774903098 hasConcept C2777714996 @default.
- W2774903098 hasConcept C2779727006 @default.
- W2774903098 hasConcept C2780333948 @default.
- W2774903098 hasConcept C2781448352 @default.
- W2774903098 hasConcept C2911091166 @default.
- W2774903098 hasConcept C71924100 @default.
- W2774903098 hasConcept C86803240 @default.
- W2774903098 hasConcept C8891405 @default.
- W2774903098 hasConcept C90924648 @default.
- W2774903098 hasConceptScore W2774903098C126322002 @default.
- W2774903098 hasConceptScore W2774903098C146357865 @default.
- W2774903098 hasConceptScore W2774903098C151730666 @default.
- W2774903098 hasConceptScore W2774903098C203014093 @default.
- W2774903098 hasConceptScore W2774903098C2776042228 @default.
- W2774903098 hasConceptScore W2774903098C2776739411 @default.
- W2774903098 hasConceptScore W2774903098C2777714996 @default.
- W2774903098 hasConceptScore W2774903098C2779727006 @default.
- W2774903098 hasConceptScore W2774903098C2780333948 @default.
- W2774903098 hasConceptScore W2774903098C2781448352 @default.
- W2774903098 hasConceptScore W2774903098C2911091166 @default.
- W2774903098 hasConceptScore W2774903098C71924100 @default.
- W2774903098 hasConceptScore W2774903098C86803240 @default.
- W2774903098 hasConceptScore W2774903098C8891405 @default.
- W2774903098 hasConceptScore W2774903098C90924648 @default.
- W2774903098 hasLocation W27749030981 @default.
- W2774903098 hasOpenAccess W2774903098 @default.
- W2774903098 hasPrimaryLocation W27749030981 @default.
- W2774903098 hasRelatedWork W1561735384 @default.
- W2774903098 hasRelatedWork W1895478142 @default.
- W2774903098 hasRelatedWork W1977300388 @default.
- W2774903098 hasRelatedWork W2005830471 @default.
- W2774903098 hasRelatedWork W2030391045 @default.
- W2774903098 hasRelatedWork W2088315796 @default.
- W2774903098 hasRelatedWork W2190944986 @default.
- W2774903098 hasRelatedWork W2404853076 @default.
- W2774903098 hasRelatedWork W2774903098 @default.
- W2774903098 hasRelatedWork W3157668598 @default.
- W2774903098 hasVolume "98" @default.
- W2774903098 isParatext "false" @default.
- W2774903098 isRetracted "false" @default.
- W2774903098 magId "2774903098" @default.
- W2774903098 workType "article" @default.