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• W2774931475 abstract "Abstract Despite the discoveries of voltage-gated sodium channels (Na v ) from a number of non-excitable cell types, the presence of Na v -mediated currents in cells of the retinal pigment epithelium (RPE) has been dismissed as a cell culture artifact. Here, we challenge this notion by demonstrating functional Na v 1.4-Na v 1.6 and Na v 1.8 channels in human embryonic stem cell derived and mouse RPE. Importantly, we show that Na v s are involved in photoreceptor outer segment phagocytosis: blocking their activity significantly reduces the efficiency of this process. Consistent with this role, Na v 1.8 co-localizes with the endosomal marker Rab7 and, during phagocytosis, with opsin. Na v 1.4 localizes strongly to the cell-cell junctions together with the gap junction protein Connexin 43. During phagocytosis, both are localized to the phagosomes with a concurrent decrease in the junctional localization. Our study demonstrates that Na v s give the capacity of fast electrical signaling to RPE and that Na v s play a novel role in photoreceptor outer segment phagocytosis." @default.
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• W2774931475 date "2017-11-22" @default.
• W2774931475 modified "2023-09-27" @default.
• W2774931475 title "Fast voltage sensitivity in retinal pigment epithelium: sodium channels and their novel role in phagocytosis" @default.
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• W2774931475 doi "https://doi.org/10.1101/223719" @default.
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