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• W2775008495 abstract "Research on the biology of NAD+ has been gaining momentum, providing many critical insights into the pathogenesis of age-associated functional decline and diseases. In particular, two key NAD+ intermediates, nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), have been extensively studied over the past several years. Supplementing these NAD+ intermediates has shown preventive and therapeutic effects, ameliorating age-associated pathophysiologies and disease conditions. Although the pharmacokinetics and metabolic fates of NMN and NR are still under intensive investigation, these NAD+ intermediates can exhibit distinct behavior, and their fates appear to depend on the tissue distribution and expression levels of NAD+ biosynthetic enzymes, nucleotidases, and presumptive transporters for each. A comprehensive concept that connects NAD+ metabolism to the control of aging and longevity in mammals has been proposed, and the stage is now set to test whether these exciting preclinical results can be translated to improve human health. Research on the biology of NAD+ has been gaining momentum, providing many critical insights into the pathogenesis of age-associated functional decline and diseases. In particular, two key NAD+ intermediates, nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), have been extensively studied over the past several years. Supplementing these NAD+ intermediates has shown preventive and therapeutic effects, ameliorating age-associated pathophysiologies and disease conditions. Although the pharmacokinetics and metabolic fates of NMN and NR are still under intensive investigation, these NAD+ intermediates can exhibit distinct behavior, and their fates appear to depend on the tissue distribution and expression levels of NAD+ biosynthetic enzymes, nucleotidases, and presumptive transporters for each. A comprehensive concept that connects NAD+ metabolism to the control of aging and longevity in mammals has been proposed, and the stage is now set to test whether these exciting preclinical results can be translated to improve human health." @default.
• W2775008495 created "2017-12-22" @default.
• W2775008495 creator A5008922330 @default.
• W2775008495 creator A5077263580 @default.
• W2775008495 creator A5081413351 @default.
• W2775008495 date "2018-03-01" @default.
• W2775008495 modified "2023-10-17" @default.
• W2775008495 title "NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR" @default.
• W2775008495 cites W1562797648 @default.
• W2775008495 cites W1760023500 @default.
• W2775008495 cites W184980440 @default.
• W2775008495 cites W1910071664 @default.
• W2775008495 cites W1956802247 @default.
• W2775008495 cites W1959721425 @default.
• W2775008495 cites W1965848369 @default.
• W2775008495 cites W1968213511 @default.
• W2775008495 cites W1968890500 @default.
• W2775008495 cites W1973901371 @default.
• W2775008495 cites W1975400918 @default.
• W2775008495 cites W1976245575 @default.
• W2775008495 cites W1984513597 @default.
• W2775008495 cites W1989674299 @default.
• W2775008495 cites W1993180847 @default.
• W2775008495 cites W1995579184 @default.
• W2775008495 cites W2002811789 @default.
• W2775008495 cites W2003701712 @default.
• W2775008495 cites W2005458257 @default.
• W2775008495 cites W2012043504 @default.
• W2775008495 cites W2012690986 @default.
• W2775008495 cites W2013844116 @default.
• W2775008495 cites W2013894613 @default.
• W2775008495 cites W2016743295 @default.
• W2775008495 cites W2018138013 @default.
• W2775008495 cites W2019240387 @default.
• W2775008495 cites W2020304127 @default.
• W2775008495 cites W2022798385 @default.
• W2775008495 cites W2023657018 @default.
• W2775008495 cites W2024850262 @default.
• W2775008495 cites W2031362233 @default.
• W2775008495 cites W2038011036 @default.
• W2775008495 cites W2040414192 @default.
• W2775008495 cites W2041236207 @default.
• W2775008495 cites W2043338692 @default.
• W2775008495 cites W2044697772 @default.
• W2775008495 cites W2046810852 @default.
• W2775008495 cites W2046938310 @default.
• W2775008495 cites W2047898810 @default.
• W2775008495 cites W2050376414 @default.
• W2775008495 cites W2055969703 @default.
• W2775008495 cites W2055969761 @default.
• W2775008495 cites W2057770806 @default.
• W2775008495 cites W2061984547 @default.
• W2775008495 cites W2066445380 @default.
• W2775008495 cites W2068054518 @default.
• W2775008495 cites W2074248426 @default.
• W2775008495 cites W2076252987 @default.
• W2775008495 cites W2082393205 @default.
• W2775008495 cites W2082763359 @default.
• W2775008495 cites W2088777855 @default.
• W2775008495 cites W2090442368 @default.
• W2775008495 cites W2092544807 @default.
• W2775008495 cites W2096773810 @default.
• W2775008495 cites W2097948853 @default.
• W2775008495 cites W2108536847 @default.
• W2775008495 cites W2110720693 @default.
• W2775008495 cites W2111614709 @default.
• W2775008495 cites W2118647245 @default.
• W2775008495 cites W2123889798 @default.
• W2775008495 cites W2127483170 @default.
• W2775008495 cites W2128749718 @default.
• W2775008495 cites W2131005104 @default.
• W2775008495 cites W2132438126 @default.
• W2775008495 cites W2139120504 @default.
• W2775008495 cites W2143320493 @default.
• W2775008495 cites W2148367532 @default.
• W2775008495 cites W2157296254 @default.
• W2775008495 cites W2160700740 @default.
• W2775008495 cites W2163282809 @default.
• W2775008495 cites W2166956025 @default.
• W2775008495 cites W2167665292 @default.
• W2775008495 cites W2167990179 @default.
• W2775008495 cites W2171748049 @default.
• W2775008495 cites W2174179366 @default.
• W2775008495 cites W2195412747 @default.
• W2775008495 cites W2197446758 @default.
• W2775008495 cites W2239653845 @default.
• W2775008495 cites W2257942016 @default.
• W2775008495 cites W2263792530 @default.
• W2775008495 cites W2284984697 @default.
• W2775008495 cites W2296761075 @default.
• W2775008495 cites W2343193821 @default.
• W2775008495 cites W2344675239 @default.
• W2775008495 cites W2346856553 @default.
• W2775008495 cites W2400466055 @default.
• W2775008495 cites W2427895239 @default.
• W2775008495 cites W2434265751 @default.
• W2775008495 cites W2461097392 @default.
• W2775008495 cites W2465287431 @default.

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