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- W2775017132 endingPage "20172062" @default.
- W2775017132 startingPage "20172062" @default.
- W2775017132 abstract "Y chromosomes typically harbour a small number of genes and an abundance of repetitive sequences. In Drosophila, the Y chromosome comprises multimegabase long segments of repetitive DNA and a handful of protein-coding genes. In mammals, the Y chromosome also harbours a disproportionally high abundance of repeats. Here, we built on a Drosophila melanogaster model in which the Y chromosome is decoupled from sexual determination. Genotypes were genetically identical for the autosomes, X chromosome, and mitochondria, but differ by the presence or dose of the Y chromosome. Addition of an extra Y chromosome had limited impact in males. However, the presence of a Y chromosome in females induced a disproportionate response in genes expressed in the ovaries as well as genes encoded by the mitochondrial genome. Furthermore, the data revealed significant consequences of Y chromosome presence in larvae neuronal tissue. This included the repression of genes implicated in reproductive behaviour, courtship, mating and synaptic function. Our findings exhibit the Y chromosome as a hotspot for sex-specific adaptation. They suggest roles for natural selection on Y-linked genetic elements exerting impact on sex-specific tissues as well as somatic tissues shared by males and females." @default.
- W2775017132 created "2017-12-22" @default.
- W2775017132 creator A5020961284 @default.
- W2775017132 creator A5045861406 @default.
- W2775017132 creator A5048119817 @default.
- W2775017132 date "2017-12-13" @default.
- W2775017132 modified "2023-10-14" @default.
- W2775017132 title "Sex-specific adaptation and genomic responses to Y chromosome presence in female reproductive and neural tissues" @default.
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- W2775017132 doi "https://doi.org/10.1098/rspb.2017.2062" @default.
- W2775017132 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5745411" @default.
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