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• W2775091487 abstract "Mesenchymal stromal cells have emerged as potential candidates for cell-based therapies to modulate the immune response in organ transplantation and repair tissues after acute or chronic injury. Preclinical studies have shown convincingly in rodent models that mesenchymal stromal cells can prolong solid organ graft survival and that they can induce immune tolerance, accelerate recovery from AKI, and promote functional improvement in chronic nephropathies. Multiple complex properties of the cells, including immunomodulatory, anti-inflammatory, and proregenerative effects, seem to contribute. The promising preclinical studies have encouraged investigators to explore the safety, tolerability, and efficacy of mesenchymal stromal cell-based therapy in pilot clinical trials, including those for bone marrow and solid organ transplantation, autoimmune diseases, and tissue and organ repair. Here, we review the available data on culture-expanded mesenchymal stromal cells tested in renal transplantation, AKI, and CKD. We also briefly discuss the relevant issues that must be addressed to ensure rigorous assessment of the safety and efficacy of mesenchymal stromal cell therapies to allow the translation of this research into the practice of clinical nephrology." @default.
• W2775091487 created "2017-12-22" @default.
• W2775091487 creator A5071836029 @default.
• W2775091487 creator A5076316519 @default.
• W2775091487 creator A5086044070 @default.
• W2775091487 date "2017-11-30" @default.
• W2775091487 modified "2023-10-15" @default.
• W2775091487 title "Clinical Translation of Mesenchymal Stromal Cell Therapies in Nephrology" @default.
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