Matches in SemOpenAlex for { <https://semopenalex.org/work/W2775096538> ?p ?o ?g. }
- W2775096538 endingPage "1610.e14" @default.
- W2775096538 startingPage "1599" @default.
- W2775096538 abstract "Eukaryotic 60S ribosomal subunits are comprised of three rRNAs and ∼50 ribosomal proteins. The initial steps of their formation take place in the nucleolus, but, owing to a lack of structural information, this process is poorly understood. Using cryo-EM, we solved structures of early 60S biogenesis intermediates at 3.3 Å to 4.5 Å resolution, thereby providing insights into their sequential folding and assembly pathway. Besides revealing distinct immature rRNA conformations, we map 25 assembly factors in six different assembly states. Notably, the Nsa1-Rrp1-Rpf1-Mak16 module stabilizes the solvent side of the 60S subunit, and the Erb1-Ytm1-Nop7 complex organizes and connects through Erb1's meandering N-terminal extension, eight assembly factors, three ribosomal proteins, and three 25S rRNA domains. Our structural snapshots reveal the order of integration and compaction of the six major 60S domains within early nucleolar 60S particles developing stepwise from the solvent side around the exit tunnel to the central protuberance." @default.
- W2775096538 created "2017-12-22" @default.
- W2775096538 creator A5010441616 @default.
- W2775096538 creator A5022809412 @default.
- W2775096538 creator A5030485553 @default.
- W2775096538 creator A5032242187 @default.
- W2775096538 creator A5036756728 @default.
- W2775096538 creator A5038575769 @default.
- W2775096538 creator A5043302393 @default.
- W2775096538 creator A5046804386 @default.
- W2775096538 creator A5057468179 @default.
- W2775096538 creator A5060010220 @default.
- W2775096538 creator A5070538109 @default.
- W2775096538 creator A5081814635 @default.
- W2775096538 date "2017-12-01" @default.
- W2775096538 modified "2023-10-17" @default.
- W2775096538 title "Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes" @default.
- W2775096538 cites W1556782336 @default.
- W2775096538 cites W1765081556 @default.
- W2775096538 cites W1803102843 @default.
- W2775096538 cites W1918704078 @default.
- W2775096538 cites W1966072209 @default.
- W2775096538 cites W1968917541 @default.
- W2775096538 cites W1968959704 @default.
- W2775096538 cites W1980595317 @default.
- W2775096538 cites W2012987716 @default.
- W2775096538 cites W2020068229 @default.
- W2775096538 cites W2024186397 @default.
- W2775096538 cites W2042418666 @default.
- W2775096538 cites W2046422192 @default.
- W2775096538 cites W2046691892 @default.
- W2775096538 cites W2049936165 @default.
- W2775096538 cites W2052022792 @default.
- W2775096538 cites W2054400779 @default.
- W2775096538 cites W2059837038 @default.
- W2775096538 cites W2060167034 @default.
- W2775096538 cites W2061016099 @default.
- W2775096538 cites W2067374400 @default.
- W2775096538 cites W2071091985 @default.
- W2775096538 cites W2079204867 @default.
- W2775096538 cites W2083751058 @default.
- W2775096538 cites W2087926131 @default.
- W2775096538 cites W2097604487 @default.
- W2775096538 cites W2105642969 @default.
- W2775096538 cites W2110808180 @default.
- W2775096538 cites W2116360991 @default.
- W2775096538 cites W2124026197 @default.
- W2775096538 cites W2124204438 @default.
- W2775096538 cites W2130966021 @default.
- W2775096538 cites W2131350133 @default.
- W2775096538 cites W2132629607 @default.
- W2775096538 cites W2134969835 @default.
- W2775096538 cites W2135835466 @default.
- W2775096538 cites W2138127002 @default.
- W2775096538 cites W2138532429 @default.
- W2775096538 cites W2139137642 @default.
- W2775096538 cites W2139881678 @default.
- W2775096538 cites W2143815085 @default.
- W2775096538 cites W2146801942 @default.
- W2775096538 cites W2149360962 @default.
- W2775096538 cites W2150790075 @default.
- W2775096538 cites W2153410912 @default.
- W2775096538 cites W2154046032 @default.
- W2775096538 cites W2154197653 @default.
- W2775096538 cites W2154714625 @default.
- W2775096538 cites W2158573927 @default.
- W2775096538 cites W2159211495 @default.
- W2775096538 cites W2160559764 @default.
- W2775096538 cites W2163341755 @default.
- W2775096538 cites W2165897045 @default.
- W2775096538 cites W2168290086 @default.
- W2775096538 cites W2172095074 @default.
- W2775096538 cites W2202399767 @default.
- W2775096538 cites W2226203144 @default.
- W2775096538 cites W2265153781 @default.
- W2775096538 cites W2407366427 @default.
- W2775096538 cites W2430959969 @default.
- W2775096538 cites W2432427150 @default.
- W2775096538 cites W2471036526 @default.
- W2775096538 cites W2533055032 @default.
- W2775096538 cites W2555449851 @default.
- W2775096538 cites W2559180185 @default.
- W2775096538 cites W2562544371 @default.
- W2775096538 cites W2580158685 @default.
- W2775096538 cites W2582687375 @default.
- W2775096538 cites W2586745337 @default.
- W2775096538 cites W2593511418 @default.
- W2775096538 cites W2606339357 @default.
- W2775096538 cites W2607084506 @default.
- W2775096538 cites W2674725791 @default.
- W2775096538 cites W2950967305 @default.
- W2775096538 doi "https://doi.org/10.1016/j.cell.2017.11.039" @default.
- W2775096538 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5745149" @default.
- W2775096538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29245012" @default.
- W2775096538 hasPublicationYear "2017" @default.
- W2775096538 type Work @default.
- W2775096538 sameAs 2775096538 @default.
- W2775096538 citedByCount "151" @default.