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- W2775101074 abstract "Background:There is a need to specify the profile of subjective cognitive decline in preclinical Alzheimer’s disease (preAD). Objectives:To explore specific items of the Subjective Cognitive Decline Questionnaire (SCD-Q) that discriminate preAD from normal aging. Methods:68 cognitively normal older adults were classified as controls (n = 52) or preAD (n = 16) according to amyloid-β (Aβ) levels. An exploratory factor analysis and item analysis of the SCD-Q were performed. Informant reports of the SCD-Q were used to corroborate the findings of self-reports. One-year neuropsychological follow-up was available. Results:Four SCD-Q factors were extracted: EM-factor (episodic memory), A-factor (attention), O-factor (organization), and L-factor (language). PreAD reported a significantly higher decline in L-factor (F(1) = 6.49; p = 0.014) and A-factor (F(1) = 4.04; p = 0.049) compared to controls, and showed a higher frequency of perceived decline in SCD-Q items related with language and executive tasks (Sig-items.) Significant discriminative powers for Aβ-positivity were found for L-factor (AUC = 0.75; p = 0.003) and A-factor (AUC = 0.74; p = 0.004). Informants in the preAD group confirmed significantly higher scores in L-factor and Sig-items. A significant time×group interaction was found in the Semantic Fluency and Stroop tests, with the preAD group showing a decrease in performance at one-year. Conclusions:Our results suggest that SCD-Q items related with language and executive decline may help in prediction algorithms to detect preAD. Validation in an independent population is needed." @default.
- W2775101074 created "2017-12-22" @default.
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- W2775101074 date "2017-12-19" @default.
- W2775101074 modified "2023-10-14" @default.
- W2775101074 title "Executive and Language Subjective Cognitive Decline Complaints Discriminate Preclinical Alzheimer’s Disease from Normal Aging" @default.
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- W2775101074 doi "https://doi.org/10.3233/jad-170627" @default.
- W2775101074 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29254090" @default.
- W2775101074 hasPublicationYear "2017" @default.