FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2775112747> ?p ?o ?g. }

• W2775112747 endingPage "196" @default.
• W2775112747 startingPage "157" @default.
• W2775112747 abstract "Hodgkin lymphoma (HL) is characterized by a rare multinucleated giant neoplastic cell in tumors largely composed of other nonmalignant immune cells. It is clear that this entity comprises distinct diseases with separate epidemiological patterns, but the precise definition of each is complicated by correlations between the major defining characteristics: age at diagnosis, histopathology, and the presence of Epstein-Barr virus (EBV) genome in the DNA of the neoplastic cells (EBV tumor status). The most common but least understood of these is EBV-negative nodular sclerosis Hodgkin lymphoma (NSHL), a strongly heritable disease of adolescents and young adults, associated with HLA class II and other immune-related genotypes. NSHL is also subject to strong environmental determinates: it dramatically increases in frequency in populations undergoing economic development and consequent social change and is associated with early childhood isolation. A second entity, defined by EBV-positivity in the tumor cells (EBV-positive HL), occurs at the two age extremes and in young adulthood associated with a history of infectious mononucleosis (IM). Moreover, it is predicted by pre-diagnostic elevated levels of specific EBV antibodies and by higher viral load and is linked to specific human leukocyte antigen (HLA) class I alleles, suggesting poor control of primary EBV infection. EBV-positive cHL is highly correlated with the second most common histopathologic subtype, mixed cellularity HL (MCHL), but the existence of incompletely characterized EBV-negative MCHL and EBV-positive NSHL precludes a definitive understanding. A less common and even more familial condition, distinct from “classical” HL, is nodular lymphocyte predominant HL (NLPHL). Here we describe the demographic patterns of the major HL subtypes and the current state of knowledge of the genetic and nongenetic risk factors." @default.
• W2775112747 created "2017-12-22" @default.
• W2775112747 creator A5029377806 @default.
• W2775112747 creator A5042010522 @default.
• W2775112747 creator A5044526750 @default.
• W2775112747 date "2017-10-06" @default.
• W2775112747 modified "2023-09-27" @default.
• W2775112747 title "The Epidemiology of Hodgkin Lymphoma" @default.
• W2775112747 cites W1504727335 @default.
• W2775112747 cites W1550570183 @default.
• W2775112747 cites W1555218304 @default.
• W2775112747 cites W1616342592 @default.
• W2775112747 cites W1794045105 @default.
• W2775112747 cites W1827434910 @default.
• W2775112747 cites W1836390862 @default.
• W2775112747 cites W1854375358 @default.
• W2775112747 cites W1872872703 @default.
• W2775112747 cites W1907522612 @default.
• W2775112747 cites W1925367549 @default.
• W2775112747 cites W1963875256 @default.
• W2775112747 cites W1964798386 @default.
• W2775112747 cites W1964837213 @default.
• W2775112747 cites W1965512384 @default.
• W2775112747 cites W1965617834 @default.
• W2775112747 cites W1965978036 @default.
• W2775112747 cites W1966871658 @default.
• W2775112747 cites W1967583434 @default.
• W2775112747 cites W1968428608 @default.
• W2775112747 cites W1969383477 @default.
• W2775112747 cites W1969582706 @default.
• W2775112747 cites W1970006069 @default.
• W2775112747 cites W1971792412 @default.
• W2775112747 cites W1972013336 @default.
• W2775112747 cites W1972168709 @default.
• W2775112747 cites W1972725743 @default.
• W2775112747 cites W1973137626 @default.
• W2775112747 cites W1974600893 @default.
• W2775112747 cites W1975728730 @default.
• W2775112747 cites W1976676411 @default.
• W2775112747 cites W1978253803 @default.
• W2775112747 cites W1979534764 @default.
• W2775112747 cites W1979784045 @default.
• W2775112747 cites W1979808430 @default.
• W2775112747 cites W1980212640 @default.
• W2775112747 cites W1980325398 @default.
• W2775112747 cites W1980991473 @default.
• W2775112747 cites W1982293621 @default.
• W2775112747 cites W1982589145 @default.
• W2775112747 cites W1983578060 @default.
• W2775112747 cites W1983763330 @default.
• W2775112747 cites W1984837081 @default.
• W2775112747 cites W1984961360 @default.
• W2775112747 cites W1985122351 @default.
• W2775112747 cites W1985512844 @default.
• W2775112747 cites W1987249959 @default.
• W2775112747 cites W1987455200 @default.
• W2775112747 cites W1988066089 @default.
• W2775112747 cites W1988463165 @default.
• W2775112747 cites W1989065947 @default.
• W2775112747 cites W1989733951 @default.
• W2775112747 cites W1990081556 @default.
• W2775112747 cites W1991720068 @default.
• W2775112747 cites W1992891812 @default.
• W2775112747 cites W1995102393 @default.
• W2775112747 cites W1996007785 @default.
• W2775112747 cites W1997876336 @default.
• W2775112747 cites W2000066029 @default.
• W2775112747 cites W2000624189 @default.
• W2775112747 cites W2000689875 @default.
• W2775112747 cites W2000986143 @default.
• W2775112747 cites W2004053519 @default.
• W2775112747 cites W2004264592 @default.
• W2775112747 cites W2005927616 @default.
• W2775112747 cites W2008577378 @default.
• W2775112747 cites W2010092269 @default.
• W2775112747 cites W2011280987 @default.
• W2775112747 cites W2011577272 @default.
• W2775112747 cites W2011764735 @default.
• W2775112747 cites W2012821483 @default.
• W2775112747 cites W2013039873 @default.
• W2775112747 cites W2013136433 @default.
• W2775112747 cites W2014964400 @default.
• W2775112747 cites W2015029317 @default.
• W2775112747 cites W2015104974 @default.
• W2775112747 cites W2015750758 @default.
• W2775112747 cites W2016455091 @default.
• W2775112747 cites W2016911400 @default.
• W2775112747 cites W2019683537 @default.
• W2775112747 cites W2021310493 @default.
• W2775112747 cites W2023948557 @default.
• W2775112747 cites W2024164289 @default.
• W2775112747 cites W2024323568 @default.
• W2775112747 cites W2025337992 @default.
• W2775112747 cites W2025833405 @default.
• W2775112747 cites W2029491958 @default.
• W2775112747 cites W2029776685 @default.
• W2775112747 cites W2032165968 @default.
• W2775112747 cites W2032458486 @default.

• next