FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2775114564> ?p ?o ?g. }

• W2775114564 endingPage "3154" @default.
• W2775114564 startingPage "3141" @default.
• W2775114564 abstract "Ca2+ entry into mitochondria is mediated by the Ca2+ uniporter-channel complex containing MCU, the Ca2+-selective pore, and associated regulatory proteins. The roles of MICU proteins are controversial. MICU1 was proposed to be necessary for MCU activity, whereas subsequent studies suggested it inhibits the channel in the low-cytoplasmic Ca2+ ([Ca2+]c) regime, a mechanism referred to as gatekeeping, that imposes a [Ca2+]c threshold for channel activation at ∼1-3 μM. Here, we measured MCU activity over a wide range of quantitatively controlled and recorded [Ca2+]c. MICU1 alone can mediate gatekeeping as well as highly cooperative activation of MCU activity, whereas the fundamental role of MICU2 is to regulate the threshold and gain of MICU1-mediated inhibition and activation of MCU. Our results provide a unifying model for the roles of the MICU1/2 heterodimer in MCU-channel regulation and suggest an evolutionary role for MICU2 in spatially restricting Ca2+ crosstalk between single inositol 1,4,5-trisphosphate receptor (InsP3R) and MCU channels." @default.
• W2775114564 created "2017-12-22" @default.
• W2775114564 creator A5023780575 @default.
• W2775114564 creator A5029525058 @default.
• W2775114564 creator A5030221375 @default.
• W2775114564 creator A5068419710 @default.
• W2775114564 date "2017-12-01" @default.
• W2775114564 modified "2023-10-16" @default.
• W2775114564 title "MICU2 Restricts Spatial Crosstalk between InsP 3 R and MCU Channels by Regulating Threshold and Gain of MICU1-Mediated Inhibition and Activation of MCU" @default.
• W2775114564 cites W1968320713 @default.
• W2775114564 cites W1986213783 @default.
• W2775114564 cites W1991055482 @default.
• W2775114564 cites W2002475003 @default.
• W2775114564 cites W2010572143 @default.
• W2775114564 cites W2052471341 @default.
• W2775114564 cites W2067841051 @default.
• W2775114564 cites W2078179312 @default.
• W2775114564 cites W2084281549 @default.
• W2775114564 cites W2092510248 @default.
• W2775114564 cites W2094770594 @default.
• W2775114564 cites W2097167248 @default.
• W2775114564 cites W2122025785 @default.
• W2775114564 cites W2139625864 @default.
• W2775114564 cites W2142294730 @default.
• W2775114564 cites W2142903428 @default.
• W2775114564 cites W2156007429 @default.
• W2775114564 cites W2165573061 @default.
• W2775114564 cites W2225852931 @default.
• W2775114564 cites W2273714400 @default.
• W2775114564 cites W2294335173 @default.
• W2775114564 cites W2322380226 @default.
• W2775114564 cites W2339517318 @default.
• W2775114564 cites W2469230412 @default.
• W2775114564 cites W2506140674 @default.
• W2775114564 cites W2583026377 @default.
• W2775114564 cites W2593990129 @default.
• W2775114564 cites W2626225645 @default.
• W2775114564 cites W4252911401 @default.
• W2775114564 doi "https://doi.org/10.1016/j.celrep.2017.11.064" @default.
• W2775114564 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5734103" @default.
• W2775114564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29241542" @default.
• W2775114564 hasPublicationYear "2017" @default.
• W2775114564 type Work @default.
• W2775114564 sameAs 2775114564 @default.
• W2775114564 citedByCount "71" @default.
• W2775114564 countsByYear W27751145642018 @default.
• W2775114564 countsByYear W27751145642019 @default.
• W2775114564 countsByYear W27751145642020 @default.
• W2775114564 countsByYear W27751145642021 @default.
• W2775114564 countsByYear W27751145642022 @default.
• W2775114564 countsByYear W27751145642023 @default.
• W2775114564 crossrefType "journal-article" @default.
• W2775114564 hasAuthorship W2775114564A5023780575 @default.
• W2775114564 hasAuthorship W2775114564A5029525058 @default.
• W2775114564 hasAuthorship W2775114564A5030221375 @default.
• W2775114564 hasAuthorship W2775114564A5068419710 @default.
• W2775114564 hasBestOaLocation W27751145641 @default.
• W2775114564 hasConcept C120665830 @default.
• W2775114564 hasConcept C121332964 @default.
• W2775114564 hasConcept C12554922 @default.
• W2775114564 hasConcept C169822122 @default.
• W2775114564 hasConcept C170493617 @default.
• W2775114564 hasConcept C173018170 @default.
• W2775114564 hasConcept C181199279 @default.
• W2775114564 hasConcept C185592680 @default.
• W2775114564 hasConcept C2777427919 @default.
• W2775114564 hasConcept C35341161 @default.
• W2775114564 hasConcept C41008148 @default.
• W2775114564 hasConcept C55493867 @default.
• W2775114564 hasConcept C86803240 @default.
• W2775114564 hasConcept C9390403 @default.
• W2775114564 hasConcept C95444343 @default.
• W2775114564 hasConcept C98539663 @default.
• W2775114564 hasConceptScore W2775114564C120665830 @default.
• W2775114564 hasConceptScore W2775114564C121332964 @default.
• W2775114564 hasConceptScore W2775114564C12554922 @default.
• W2775114564 hasConceptScore W2775114564C169822122 @default.
• W2775114564 hasConceptScore W2775114564C170493617 @default.
• W2775114564 hasConceptScore W2775114564C173018170 @default.
• W2775114564 hasConceptScore W2775114564C181199279 @default.
• W2775114564 hasConceptScore W2775114564C185592680 @default.
• W2775114564 hasConceptScore W2775114564C2777427919 @default.
• W2775114564 hasConceptScore W2775114564C35341161 @default.
• W2775114564 hasConceptScore W2775114564C41008148 @default.
• W2775114564 hasConceptScore W2775114564C55493867 @default.
• W2775114564 hasConceptScore W2775114564C86803240 @default.
• W2775114564 hasConceptScore W2775114564C9390403 @default.
• W2775114564 hasConceptScore W2775114564C95444343 @default.
• W2775114564 hasConceptScore W2775114564C98539663 @default.
• W2775114564 hasIssue "11" @default.
• W2775114564 hasLocation W27751145641 @default.
• W2775114564 hasLocation W27751145642 @default.
• W2775114564 hasLocation W27751145643 @default.
• W2775114564 hasLocation W27751145644 @default.
• W2775114564 hasLocation W27751145645 @default.
• W2775114564 hasOpenAccess W2775114564 @default.
• W2775114564 hasPrimaryLocation W27751145641 @default.
• W2775114564 hasRelatedWork W2003582307 @default.

• next