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- W2775116549 abstract "Geometrical cues have been shown to alter gene expression and differentiation on 2D substrates. However, little is known about how geometrical cues affect cell function in 3D. One major reason for this lack of understanding is rooted in the difficulties of controlling cell geometry in a complex 3D setting and for long periods of culture. Here, we present a robust method to control cell volume and shape of individual human mesenchymal stem cells (hMSCs) inside 3D microniches with a range of different geometries (e.g., cylinder, triangular prism, cubic, and cuboid). We find that the actin filaments, focal adhesions, nuclear shape, YAP/TAZ localization, cell contractility, nuclear accumulation of histone deacetylase 3, and lineage selection are all sensitive to cell volume. Our 3D microniches enable fundamental studies on the impact of biophysical cues on cell fate, and have potential applications in investigating how multicellular architectures organize within geometrically well-defined 3D spaces." @default.
- W2775116549 created "2017-12-22" @default.
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- W2775116549 date "2017-12-01" @default.
- W2775116549 modified "2023-10-16" @default.
- W2775116549 title "3D microniches reveal the importance of cell size and shape" @default.
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- W2775116549 doi "https://doi.org/10.1038/s41467-017-02163-2" @default.
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