FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2775127989> ?p ?o ?g. }

• W2775127989 endingPage "55" @default.
• W2775127989 startingPage "50" @default.
• W2775127989 abstract "Topicality. The world is facing a heavy items of thyroid gland diseases. Hypothyroidism is the most common thyroid dysfunction. Its prevalence in the general population is almost 2 %, and in some age groups (elderly women) can reach 6-8 % and is constantly increasing. The search and creation of safe and effective medicines of plant origin with minimized side manifestations is relevant and considered a promising area in the treatment of thyroid diseases.Aim. To determine the development degree of the hypothyroid state in rats and the establishment of the corrective effect of Laminaria aqueous extract on the thyroid morphological structure.Materials and methods. The experimental model of hypothyroidism is induced by oral administration of sodium perchlorate.Extract from Laminaria in a liquid form is made at the Department of Quality, Standardization and Certification of drugs in NUPh and is studied as a thyroid stimulating agent. Iodomarin was used as reference drug.Results and discussion. Changes in thyroid gland structure , which were diffused in nature, were observed in animals of pathology group model. The same changes were observed in all rats with certain fluctuations in the severity of hyperplastic processes. Changes in the structure of the follicles were reflected in the morphometric characteristics: the average external diameter of the follicles, the height of the thyrocytes and their number were significantly increased compared to intact animals. The absolute mass of the thyroid gland was increased by 1.72 folds, which indicates the goitrogenic effect of sodium perchlorate. Treatment of hypothyroid rats with the aqueous extract from Laminaria practically completely restored histological structure of thyroid gland to the status of intact animals. Morphometric indexes (with the exception of the external diameter of the follicles) and the mass of the thyroid gland did not return to the values of the IC, which may indicate a partial restoration of the functional activity of the thyroid gland. Iodomarin and extract from Laminaria cause a one-way action to the thyroid morphological structure.Conclusions. The investigated Laminaria aqueous extract in animals with perchlorate-induced hypothyroidism showed a clear corrective effect on the morphological state of the thyroid gland, practically restoring its structural and functional properties, and exceeded the efficiency of the reference drug Iodomarin." @default.
• W2775127989 created "2017-12-22" @default.
• W2775127989 creator A5016208506 @default.
• W2775127989 creator A5040341721 @default.
• W2775127989 creator A5045173386 @default.
• W2775127989 creator A5086364522 @default.
• W2775127989 date "2017-12-01" @default.
• W2775127989 modified "2023-09-25" @default.
• W2775127989 title "Investigation of Laminaria aqueous extract effect on thyroid gland morphological status in rats with experimental hypothyroidism induced by sodium perchlorate" @default.
• W2775127989 doi "https://doi.org/10.24959/ubphj.17.144" @default.
• W2775127989 hasPublicationYear "2017" @default.
• W2775127989 type Work @default.
• W2775127989 sameAs 2775127989 @default.
• W2775127989 citedByCount "4" @default.
• W2775127989 countsByYear W27751279892022 @default.
• W2775127989 countsByYear W27751279892023 @default.
• W2775127989 crossrefType "journal-article" @default.
• W2775127989 hasAuthorship W2775127989A5016208506 @default.
• W2775127989 hasAuthorship W2775127989A5040341721 @default.
• W2775127989 hasAuthorship W2775127989A5045173386 @default.
• W2775127989 hasAuthorship W2775127989A5086364522 @default.
• W2775127989 hasConcept C126322002 @default.
• W2775127989 hasConcept C134018914 @default.
• W2775127989 hasConcept C145148216 @default.
• W2775127989 hasConcept C178790620 @default.
• W2775127989 hasConcept C185592680 @default.
• W2775127989 hasConcept C2780709120 @default.
• W2775127989 hasConcept C2908647359 @default.
• W2775127989 hasConcept C42407357 @default.
• W2775127989 hasConcept C526584372 @default.
• W2775127989 hasConcept C71924100 @default.
• W2775127989 hasConcept C99454951 @default.
• W2775127989 hasConceptScore W2775127989C126322002 @default.
• W2775127989 hasConceptScore W2775127989C134018914 @default.
• W2775127989 hasConceptScore W2775127989C145148216 @default.
• W2775127989 hasConceptScore W2775127989C178790620 @default.
• W2775127989 hasConceptScore W2775127989C185592680 @default.
• W2775127989 hasConceptScore W2775127989C2780709120 @default.
• W2775127989 hasConceptScore W2775127989C2908647359 @default.
• W2775127989 hasConceptScore W2775127989C42407357 @default.
• W2775127989 hasConceptScore W2775127989C526584372 @default.
• W2775127989 hasConceptScore W2775127989C71924100 @default.
• W2775127989 hasConceptScore W2775127989C99454951 @default.
• W2775127989 hasIssue "6(53)" @default.
• W2775127989 hasLocation W27751279891 @default.
• W2775127989 hasOpenAccess W2775127989 @default.
• W2775127989 hasPrimaryLocation W27751279891 @default.
• W2775127989 hasRelatedWork W1981968121 @default.
• W2775127989 hasRelatedWork W2010645160 @default.
• W2775127989 hasRelatedWork W2011960454 @default.
• W2775127989 hasRelatedWork W2060603500 @default.
• W2775127989 hasRelatedWork W2070704005 @default.
• W2775127989 hasRelatedWork W2072870574 @default.
• W2775127989 hasRelatedWork W2155312245 @default.
• W2775127989 hasRelatedWork W2163236351 @default.
• W2775127989 hasRelatedWork W2411536504 @default.
• W2775127989 hasRelatedWork W2748952813 @default.
• W2775127989 hasVolume "0" @default.
• W2775127989 isParatext "false" @default.
• W2775127989 isRetracted "false" @default.
• W2775127989 magId "2775127989" @default.
• W2775127989 workType "article" @default.