FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2775137746> ?p ?o ?g. }

• W2775137746 endingPage "1369" @default.
• W2775137746 startingPage "1356" @default.
• W2775137746 abstract "ABSTRACT Degenerative disk disease of the spine is a major cause of back pain and disability. Optimization of regenerative medical therapies for degenerative disk disease requires a deep mechanistic understanding of the factors controlling the structural integrity of spinal tissues. In this investigation, we sought to identify candidate regulatory genes controlling extracellular matrix synthesis in spinal tissues. To achieve this goal we performed high throughput next generation RNA sequencing on 39 annulus fibrosus and 21 nucleus pulposus human tissue samples. Specimens were collected from patients undergoing surgical discectomy for the treatment of degenerative disk disease. Our studies identified associations between extracellular matrix genes, growth factors, and other important regulatory molecules. The fibrous matrix characteristic of annulus fibrosus was associated with expression of the growth factors platelet derived growth factor beta (PDGFB), vascular endothelial growth factor C (VEGFC), and fibroblast growth factor 9 (FGF9). Additionally we observed high expression of multiple signaling proteins involved in the NOTCH and WNT signaling cascades. Nucleus pulposus extracellular matrix related genes were associated with the expression of numerous diffusible growth factors largely associated with the transforming growth signaling cascade, including transforming factor alpha (TGFA), inhibin alpha (INHA), inhibin beta A (INHBA), bone morphogenetic proteins (BMP2, BMP6), and others. Clinical significance: this investigation provides important data on extracellular matrix gene regulatory networks in disk tissues. This information can be used to optimize pharmacologic, stem cell, and tissue engineering strategies for regeneration of the intervertebral disk and the treatment of back pain. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1356–1369, 2018." @default.
• W2775137746 created "2017-12-22" @default.
• W2775137746 creator A5004881804 @default.
• W2775137746 creator A5008755139 @default.
• W2775137746 creator A5016934014 @default.
• W2775137746 creator A5019240237 @default.
• W2775137746 creator A5030704684 @default.
• W2775137746 creator A5032599962 @default.
• W2775137746 creator A5035972380 @default.
• W2775137746 creator A5037231056 @default.
• W2775137746 creator A5039038647 @default.
• W2775137746 creator A5046597133 @default.
• W2775137746 creator A5047603903 @default.
• W2775137746 creator A5048689751 @default.
• W2775137746 creator A5054976158 @default.
• W2775137746 creator A5055312058 @default.
• W2775137746 creator A5060758786 @default.
• W2775137746 creator A5063475404 @default.
• W2775137746 creator A5077793991 @default.
• W2775137746 creator A5082411048 @default.
• W2775137746 creator A5083145055 @default.
• W2775137746 date "2018-01-10" @default.
• W2775137746 modified "2023-10-08" @default.
• W2775137746 title "RNA sequencing identifies gene regulatory networks controlling extracellular matrix synthesis in intervertebral disk tissues" @default.
• W2775137746 cites W106776827 @default.
• W2775137746 cites W114757092 @default.
• W2775137746 cites W1817479092 @default.
• W2775137746 cites W1963501822 @default.
• W2775137746 cites W1966327575 @default.
• W2775137746 cites W1969154370 @default.
• W2775137746 cites W1973057151 @default.
• W2775137746 cites W1977595180 @default.
• W2775137746 cites W1980794230 @default.
• W2775137746 cites W1991332628 @default.
• W2775137746 cites W1997980872 @default.
• W2775137746 cites W2003146566 @default.
• W2775137746 cites W2005918147 @default.
• W2775137746 cites W2019476547 @default.
• W2775137746 cites W2032518686 @default.
• W2775137746 cites W2039818918 @default.
• W2775137746 cites W2043854809 @default.
• W2775137746 cites W2048442741 @default.
• W2775137746 cites W2052230687 @default.
• W2775137746 cites W2071448535 @default.
• W2775137746 cites W2074475825 @default.
• W2775137746 cites W2075912613 @default.
• W2775137746 cites W2080209376 @default.
• W2775137746 cites W2093387976 @default.
• W2775137746 cites W2098082628 @default.
• W2775137746 cites W2124078280 @default.
• W2775137746 cites W2124694620 @default.
• W2775137746 cites W2124985265 @default.
• W2775137746 cites W2127956592 @default.
• W2775137746 cites W2132638280 @default.
• W2775137746 cites W2134513968 @default.
• W2775137746 cites W2134526812 @default.
• W2775137746 cites W2138383018 @default.
• W2775137746 cites W2140476594 @default.
• W2775137746 cites W2140729960 @default.
• W2775137746 cites W2141424953 @default.
• W2775137746 cites W2146617670 @default.
• W2775137746 cites W2157132102 @default.
• W2775137746 cites W2158217645 @default.
• W2775137746 cites W2162292941 @default.
• W2775137746 cites W2177193863 @default.
• W2775137746 cites W2283726268 @default.
• W2775137746 cites W2412689777 @default.
• W2775137746 cites W2510575190 @default.
• W2775137746 cites W2559525415 @default.
• W2775137746 cites W4293875690 @default.
• W2775137746 cites W4319307142 @default.
• W2775137746 cites W79708563 @default.
• W2775137746 doi "https://doi.org/10.1002/jor.23834" @default.
• W2775137746 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5990467" @default.
• W2775137746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29227558" @default.
• W2775137746 hasPublicationYear "2018" @default.
• W2775137746 type Work @default.
• W2775137746 sameAs 2775137746 @default.
• W2775137746 citedByCount "24" @default.
• W2775137746 countsByYear W27751377462019 @default.
• W2775137746 countsByYear W27751377462020 @default.
• W2775137746 countsByYear W27751377462021 @default.
• W2775137746 countsByYear W27751377462022 @default.
• W2775137746 countsByYear W27751377462023 @default.
• W2775137746 crossrefType "journal-article" @default.
• W2775137746 hasAuthorship W2775137746A5004881804 @default.
• W2775137746 hasAuthorship W2775137746A5008755139 @default.
• W2775137746 hasAuthorship W2775137746A5016934014 @default.
• W2775137746 hasAuthorship W2775137746A5019240237 @default.
• W2775137746 hasAuthorship W2775137746A5030704684 @default.
• W2775137746 hasAuthorship W2775137746A5032599962 @default.
• W2775137746 hasAuthorship W2775137746A5035972380 @default.
• W2775137746 hasAuthorship W2775137746A5037231056 @default.
• W2775137746 hasAuthorship W2775137746A5039038647 @default.
• W2775137746 hasAuthorship W2775137746A5046597133 @default.
• W2775137746 hasAuthorship W2775137746A5047603903 @default.
• W2775137746 hasAuthorship W2775137746A5048689751 @default.
• W2775137746 hasAuthorship W2775137746A5054976158 @default.

• next