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- W2775174941 abstract "The polymerase-associated factor 1 complex (Paf1C) regulates RNA polymerase II transcription and is required for the monoubiquitylation of histone H2B (H2Bub), a conserved epigenetic modification with broad implications for the regulation of gene expression and human health. This dissertation explores the molecular mechanisms by which Paf1C acts to promote H2Bub. Paf1C regulation of H2Bub is governed largely by the histone modification domain (HMD) ofthe Rtf1 subunit, which promotes H2Bub even in the absence of all Paf1C subunits and interacts directly with the enzyme that catalyzes H2Bub. The role of the HMD in stimulating H2Bub is direct, and at least partially independent of transcription. My work is part of a collaborative effort to investigate the activity of the HMD through structural, genetic, bioinformatic, andbiochemical approaches. As the influence of H2Bub on human health continues to become more clear, interest in this modification will likely continue to expand." @default.
- W2775174941 created "2017-12-22" @default.
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- W2775174941 date "2017-09-28" @default.
- W2775174941 modified "2023-09-24" @default.
- W2775174941 title "Insights into the role of the Paf1 complex in promoting H2B monoubiquitylation" @default.
- W2775174941 hasPublicationYear "2017" @default.
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