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- W2775185492 abstract "The development of new drugs has become challenging as the necessary investments in time and money have increased while drug approval rates have decreased. A potential solution to this problem is drug repositioning which aims to use existing drugs to treat conditions for which they were not originally intended. One approach that may enhance the likelihood of success is to reposition drugs against a target that has a genetic basis. The multitude of genome-wide association studies (GWASs) conducted in recent years represents a large potential pool of novel targets for drug repositioning. Although trait-associated variants identified from GWAS still need to be causally linked to a target gene, recently developed functional genomic techniques, databases, and workflows are helping to remove this bottleneck. The pre-clinical validation of repositioning against these targets also needs to be carefully performed to ensure that findings are not confounded by off-target effects or limitations of the techniques used. Nevertheless, the approaches described in this review have the potential to provide a faster, cheaper and more certain route to clinical approval." @default.
- W2775185492 created "2017-12-22" @default.
- W2775185492 creator A5012470916 @default.
- W2775185492 creator A5063134447 @default.
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- W2775185492 date "2017-12-06" @default.
- W2775185492 modified "2023-10-16" @default.
- W2775185492 title "Enhancing the Promise of Drug Repositioning through Genetics" @default.
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- W2775185492 cites W1969208427 @default.
- W2775185492 cites W1976844911 @default.
- W2775185492 cites W1980991473 @default.
- W2775185492 cites W1981409633 @default.
- W2775185492 cites W1991838121 @default.
- W2775185492 cites W2001280003 @default.
- W2775185492 cites W2002715948 @default.
- W2775185492 cites W2010789111 @default.
- W2775185492 cites W2012486622 @default.
- W2775185492 cites W2018518196 @default.
- W2775185492 cites W2028279608 @default.
- W2775185492 cites W2028335133 @default.
- W2775185492 cites W2046579578 @default.
- W2775185492 cites W2063280109 @default.
- W2775185492 cites W2064645845 @default.
- W2775185492 cites W2067833766 @default.
- W2775185492 cites W2076154138 @default.
- W2775185492 cites W2079177924 @default.
- W2775185492 cites W2094379190 @default.
- W2775185492 cites W2097660065 @default.
- W2775185492 cites W2112128505 @default.
- W2775185492 cites W2112848098 @default.
- W2775185492 cites W2113105800 @default.
- W2775185492 cites W2113974339 @default.
- W2775185492 cites W2118258530 @default.
- W2775185492 cites W2118822739 @default.
- W2775185492 cites W2121604817 @default.
- W2775185492 cites W2121850120 @default.
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- W2775185492 cites W2185693210 @default.
- W2775185492 cites W2202954603 @default.
- W2775185492 cites W2204695023 @default.
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- W2775185492 cites W2514270659 @default.
- W2775185492 cites W2519241029 @default.
- W2775185492 cites W2537623931 @default.
- W2775185492 cites W2539721631 @default.
- W2775185492 cites W2557530941 @default.
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- W2775185492 doi "https://doi.org/10.3389/fphar.2017.00896" @default.
- W2775185492 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5724196" @default.
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