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• W2775194855 abstract "Immune privilege protects the eye from sight-threatening immunoinflammatory responses. The factors that orchestrate ocular immune privilege continue to be defined. Current work in the field is focused on the immunoregulatory processes that conspire to limit the effector response. Our understanding of epithelium-derived immunoregulatory factors, ocular surface dendritic cells, neuroimmune crosstalk, the ocular surface microbiome, memory type 17 T helper (Th17) cells in autoimmunity, and CD4+ T cell plasticity at the ocular surface has deepened markedly over recent years. Recent findings suggest novel treatment strategies to suppress autoimmunity and promote allotolerance, for instance by modulating CD4+ T cell chemotaxis and expanding regulatory T cell populations. The ocular surface is a unique mucosal immune compartment in which anatomical, physiological, and immunological features act in concert to foster a particularly tolerant microenvironment. These mechanisms are vital to the functional competence of the eye, a fact underscored by the devastating toll of excessive inflammation at the cornea – blindness. Recent data have elucidated the contributions of specific anatomical components, immune cells, and soluble immunoregulatory factors in promoting homeostasis at the ocular surface. We highlight research trends at this distinctive mucosal barrier and identify crucial gaps in our current knowledge. The ocular surface is a unique mucosal immune compartment in which anatomical, physiological, and immunological features act in concert to foster a particularly tolerant microenvironment. These mechanisms are vital to the functional competence of the eye, a fact underscored by the devastating toll of excessive inflammation at the cornea – blindness. Recent data have elucidated the contributions of specific anatomical components, immune cells, and soluble immunoregulatory factors in promoting homeostasis at the ocular surface. We highlight research trends at this distinctive mucosal barrier and identify crucial gaps in our current knowledge." @default.
• W2775194855 created "2017-12-22" @default.
• W2775194855 creator A5000474393 @default.
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• W2775194855 creator A5054884880 @default.
• W2775194855 creator A5074051789 @default.
• W2775194855 date "2018-04-01" @default.
• W2775194855 modified "2023-10-12" @default.
• W2775194855 title "When Clarity Is Crucial: Regulating Ocular Surface Immunity" @default.
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