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- W2775215939 abstract "In-vitro permeation studies were conducted to assess the feasibility of fabricating dissolving-microneedle-array systems to release sumatriptan succinate. The formulations consisted mainly of the encapsulated active ingredient and a water-soluble biologically compatible polymer, polyvinylpyrrolidone (PVP), approved by the U.S. Food and Drug Administration (FDA). Tests with Franz-type diffusion cells and Göttingen minipig skins showed an increase of the transdermal flux compared to passive diffusion. A preparation, containing 30% by mass of PVP and 8.7mg sumatriptan, produced a delivery rate of 395±31μg/cm2h over a 7-hour period after a negligible lag time of approximately 39min. Theoretically, a 10.7cm2 microneedle-array patch loaded with 118.8mg of the drug would provide the required plasma concentration, 72ng/mL, for nearly 7h." @default.
- W2775215939 created "2017-12-22" @default.
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- W2775215939 date "2018-03-01" @default.
- W2775215939 modified "2023-10-01" @default.
- W2775215939 title "Dissolving polyvinylpyrrolidone-based microneedle systems for in-vitro delivery of sumatriptan succinate" @default.
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- W2775215939 doi "https://doi.org/10.1016/j.ejps.2017.11.031" @default.
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