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• W2775216426 abstract "The suitability of crayfish (Orconectes rusticus) for drug addiction research arises from developmental variation of growth, life span, reproduction, behavior and some quantitative traits, especially among isogenic mates reared in the same environment. This broad spectrum of traits makes it easier to analyze the effect of mammalian drugs of abuse in shaping behavioral phenotype. Moreover, the broad behavioral repertoire allows the investigation of self-reinforcing circuitries involving appetitive and exploratory motor behavior, while the step-wise alteration of the phenotype by metamorphosis allows accurate longitudinal analysis of different behavioral states. This paper reviews a series of recent experimental findings that reveal the suitability of crayfish as an invertebrate model system for the study of drug addiction. Results from these studies reveal that unconditioned exposure to mammalian drugs of abuse produces a variety of stereotyped behaviors. Moreover, if presented in the context of novelty, drugs directly stimulate exploration and appetitive motor patterns along with molecular processes for drug conditioned reward. Findings from these studies indicate the existence of drug sensitive circuitry in crayfish that facilitates exploratory behavior and appetitive motor patterns via increased incentive salience of environmental stimuli or by increasing exploratory motor patterns. This work demonstrates the potential of crayfish as a model system for research into the neural mechanisms of addiction, by contributing an evolutionary, comparative context to our understanding of natural reward as an important life-sustaining process." @default.
• W2775216426 created "2017-12-22" @default.
• W2775216426 creator A5019841925 @default.
• W2775216426 creator A5021275080 @default.
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• W2775216426 creator A5056129607 @default.
• W2775216426 creator A5063784115 @default.
• W2775216426 creator A5065536680 @default.
• W2775216426 date "2017-12-06" @default.
• W2775216426 modified "2023-09-27" @default.
• W2775216426 title "The Sensitivity of the Crayfish Reward System to Mammalian Drugs of Abuse" @default.
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